Recruitment of Shp-2 to pSirp alpha

Stable Identifier
R-RNO-548968
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Recruitment of Shp-2 to pSirp alpha
SIRP alpha functions as a docking protein. The tyrosine-phosphorylated residues of SIRP alpha trigger the binding and activation of tyrosine phosphatases SHP-1 and SHP-2. All four phosphotyrosines of SIRP alpha may serve as substrates for SHP-1 and SHP-2. SIRP alpha binds mostly to SHP-1 in hematopoietic cells and with SHP-2 in non-hematopoietic cells. These phosphatases mediate the specific functions of SIRP alpha.
Literature References
PubMed ID Title Journal Year
9582366 Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases

Noguchi, T, Fujioka, Y, Takada, T, Imamoto, A, Yamamoto, T, Ochi, F, Kasuga, M, Fukunaga, K, Matozaki, T, Tsuda, M, Yamao, T, Takeda, H

J Biol Chem 1998
9507023 Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association

Carter-Su, C, Stofega, MR, Ullrich, A, Wang, H

J Biol Chem 1998
Participants
Orthologous Events
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