Phosphorylation of ITIM in SIRP alpha

Stable Identifier
R-RNO-548972
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Phosphorylation of ITIM in SIRP alpha

Various growth factors and events such as integrin-mediated cell adhesion to extracellular matrix (ECM) proteins induce the tyrosine phosphorylation of SIRP alpha. The cytoplasmic tail of SIRP alpha has two ITIMs with four tyrosine residues that are potential sites for phosphorylation. Phosphorylation is not dependent on CD47 engagement but the presence of CD47 may enhance the effect. Src family kinases may be involved in the phosphorylation.

Literature References
PubMed ID Title Journal Year
9582366 Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2. Roles of Fak and Src family kinases

Tsuda, M, Matozaki, T, Fukunaga, K, Fujioka, Y, Imamoto, A, Noguchi, T, Takada, T, Yamao, T, Takeda, H, Ochi, F, Yamamoto, T, Kasuga, M

J Biol Chem 1998
Participants
Catalyst Activity

protein tyrosine kinase activity of Src kinase Src/FAK1 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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