Reactome | ARF4 [cytosol]

ARF4 [cytosol]

Stable Identifier

R-RNO-5618178

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

P61751

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPI-mediated anterograde transport (Rattus norvegicus)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        Active ARF recruits coatomer (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPI-mediated anterograde transport (Rattus norvegicus)
      - ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
      - ARFGAPs stimulate ARF GTPase activity (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
      - Active ARF recruits coatomer (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
      - GBF1 recruits ARF:GDP to the ERGIC (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
      - GBF1 stimulates ARF nucleotide exchange (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GDP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
  - Intra-Golgi and retrograde Golgi-to-ER traffic (Rattus norvegicus)
    - Golgi-to-ER retrograde transport (Rattus norvegicus)
      - COPI-dependent Golgi-to-ER retrograde traffic (Rattus norvegicus)
        
        ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        Active ARF recruits coatomer to the Golgi (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP:coatomer [Golgi membrane] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        GBF1 recruits ARF:GDP to the Golgi (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        GBF1 stimulates nucleotide exchange on ARF (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GDP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GDP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)
        
        RAB1:GTP:GBF1:ARF:GTP [Golgi membrane] (Rattus norvegicus)
        
        ARF:GTP [cytosol] (Rattus norvegicus)
        
        ARFs [cytosol] (Rattus norvegicus)
        
        ARF4 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P61751

Reference Genes

BioGPS Gene:79120

ENSEMBL:ENSRNOG00000012623

ENSEMBL:ENSRNOG00000012623.6

ENSEMBL:ENSRNOG00055021532

ENSEMBL:ENSRNOG00060013369

ENSEMBL:ENSRNOG00065014219

KEGG Gene (Rattus norvegicus):79120

Monarch:79120

NCBI Gene:79120

UCSC:P61751

Reference Transcript

RefSeq:NM_024151.1

Other Identifiers

10786228

1398758_at

17705719

5687610

5774277

5896094

5932170

6054172

6071773

6264262

6318439

6479685

6618449

79120

A_44_P384223

GE1178128

GE21855

GO:0003824

GO:0003924

GO:0005525

GO:0016787

ILMN_1358093

L12383_at

PH_rn_0014958

Participates

as a component of

as a member of

ARFs [cytosol] (Rattus norvegicus)

Inferred From

ARF4 [cytosol] (Homo sapiens)

Modified Residues

Name

N-myristoylglycine at 2 (in Homo sapiens)

Coordinate

PsiMod Name

N-myristoylglycine [MOD:00068]

PsiMod Definition

A protein modification that effectively converts a glycine residue to N-myristoylglycine.

Cross References

RefSeq

NP_077065.1

Ensembl

ENSRNOP00000017692, ENSRNOG00000012623, ENSRNOT00000017692

PRO

P61751

RGD

621275

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