Reactome | TNFRSF10A [plasma membrane]

TNFRSF10A [plasma membrane]

Stable Identifier

R-RNO-5633393

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

A0A0G2JZE1

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Rattus norvegicus)

- Apoptosis (Rattus norvegicus)
  - Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
    - Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
      - Dimerization of procaspase-8 (Rattus norvegicus)
        
        TRAIL-mediated dimerization of procaspase-8 (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:2xCASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
      - Regulation by c-FLIP (Rattus norvegicus)
        
        Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
        
        DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer in TRAIL signaling (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479) [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD:CASP8(1-479):CFLAR [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
- Regulated Necrosis (Rattus norvegicus)
  - RIPK1-mediated regulated necrosis (Rattus norvegicus)
    - Regulation of necroptotic cell death (Rattus norvegicus)
      - CASP8 activity is inhibited (Rattus norvegicus)
        
        FLIP(L) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(L) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        FLIP(S) and procaspase-8 form heterodimer (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8:FLIP(S) [plasma membrane] (Rattus norvegicus)
        
        DISC:procaspase-8 [plasma membrane] (Rattus norvegicus)
        
        DISC [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B:FADD [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B Trimer [plasma membrane] (Rattus norvegicus)
        
        TNFSF10:TNFRSF10A,B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)
        
        TNFRSF10A [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JZE1

Reference Genes

ENSEMBL:ENSRNOG00000038483

UCSC:A0A0G2JZE1

Other Identifiers

10781321

1395079_at

17699867

364420

5796882

5966540

6141672

6292131

6441092

6464809

6524518

6543991

6743636

A_44_P102857

A_64_P095438

GO:0002020

GO:0004888

GO:0005515

GO:0005794

GO:0005829

GO:0005886

GO:0006915

GO:0007165

GO:0008584

GO:0008625

GO:0009986

GO:0016020

GO:0036462

GO:0042802

GO:0044853

GO:0045121

GO:0045569

GO:0071260

GO:0097191

ILMN_1360982

PH_rn_0009739

Participates

as a component of

TNFRSF10A:TNFRSF10D [plasma membrane] (Rattus norvegicus)

as a member of

TNFRSF10A,TNFRSF10B [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

TNFRSF10D [plasma membrane]

TNFRSF10B [plasma membrane]

Inferred From

TNFRSF10A [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOT00000066128, ENSRNOP00000063335, ENSRNOG00000038483

RGD

1308041

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