Reactome | BRCC3 [nucleoplasm]

BRCC3 [nucleoplasm]

Stable Identifier

R-RNO-5682577

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

B2RYM5

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - G2/M DNA damage checkpoint (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)

DNA Repair (Rattus norvegicus)

- DNA Double-Strand Break Repair (Rattus norvegicus)
  - DNA Double Strand Break Response (Rattus norvegicus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
      - CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
      - Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
  - Homology Directed Repair (Rattus norvegicus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
      - Processing of DNA double-strand break ends (Rattus norvegicus)
        
        PIAS4 SUMOylates MDC1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)
  - Nonhomologous End-Joining (NHEJ) (Rattus norvegicus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)
      - BRCC3 [nucleoplasm] (Rattus norvegicus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        BRCC3 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:B2RYM5

Reference Genes

BioGPS Gene:316794

ENSEMBL:ENSRNOG00000048061

ENSEMBL:ENSRNOG00055016606

ENSEMBL:ENSRNOG00060026217

ENSEMBL:ENSRNOG00065014364

KEGG:rno:316794

Monarch:316794

NCBI Gene:316794

UCSC:B2RYM5

Reference Transcript

RefSeq:NM_001127300.1

Other Identifiers

1374318_at

1381115_at

17870216

316794

5643981

5680744

5809097

5917138

5990699

6474203

6644613

6690624

A_44_P429254

A_64_P127511

GE1136851

GE1246126

GO:0003824

GO:0004843

GO:0005515

GO:0005634

GO:0006281

GO:0008233

GO:0008237

GO:0016787

GO:0036211

GO:0043226

GO:0070531

GO:0070536

GO:0070552

GO:0140096

ILMN_1349611

PH_rn_0004448

rc_AA891851_at

rc_AI639176_at

Participates

as an output of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)

as a component of

as an input of

Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)

Other forms of this molecule

BRCC3 [cytosol]

Inferred From

BRCC3 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001120772.1

ENSEMBL

ENSRNOP00000066438, ENSRNOT00000071068

PRO

B2RYM5

RGD

1588543

Cite Us!