Reactome | Babam1 [nucleoplasm]

Babam1 [nucleoplasm]

Stable Identifier

R-RNO-5682582

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

BABAM1, Q5XIJ6

Locations in the PathwayBrowser

Expand all

Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - G2/M Checkpoints (Rattus norvegicus)
    - G2/M DNA damage checkpoint (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)

DNA Repair (Rattus norvegicus)

- DNA Double-Strand Break Repair (Rattus norvegicus)
  - DNA Double Strand Break Response (Rattus norvegicus)
    - Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Rattus norvegicus)
      - CHEK2 is recruited to DNA DSBs (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
      - CHEK2 phosphorylates BRCA1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
      - Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation and activation of CHEK2 by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
      - Phosphorylation of BRCA1-A complex at multiple sites by ATM (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-4S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
  - Homology Directed Repair (Rattus norvegicus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
      - Processing of DNA double-strand break ends (Rattus norvegicus)
        
        PIAS4 SUMOylates MDC1 (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
        
        DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)
  - Nonhomologous End-Joining (NHEJ) (Rattus norvegicus)
    - RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)
      - Babam1 [nucleoplasm] (Rattus norvegicus)
      - DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] (Rattus norvegicus)
        
        p-5S,2T-BRCA1-A Complex [nucleoplasm] (Rattus norvegicus)
        
        Babam1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5XIJ6

Gene Names

Babam1

Reference Genes

BioGPS Gene:290631 Babam1

ENSEMBL:ENSRNOG00000017071

ENSEMBL:ENSRNOG00055010549

ENSEMBL:ENSRNOG00060011253

ENSEMBL:ENSRNOG00065000640

ENSEMBL:ENSRNOG00065020442

KEGG:rno:290631 Babam1

Monarch:290631 Babam1

NCBI Gene:290631 Babam1

UCSC:Q5XIJ6 Babam1

Reference Transcript

Other Identifiers

10787266

1371992_at

17706836

290631

5676431

5698704

5779684

5844640

5910601

6042494

6193958

6242356

6312888

6453847

6512053

6514657

6745525

A_44_P203769

A_64_P077627

GE14006

GO:0000278

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006281

GO:0006302

GO:0006325

GO:0007095

GO:0010212

GO:0016604

GO:0023052

GO:0030154

GO:0043226

GO:0045739

GO:0048856

GO:0070531

GO:0070552

GO:0071425

GO:0140861

ILMN_1363345

PH_rn_0014340

rc_AI104376_at

Participates

as an output of

RIF1 and PAX1IP bind TP53BP1 at DNA DSBs (Rattus norvegicus)

as a component of

as an input of

Formation of BRCA1-A complex at DNA DSBs (Rattus norvegicus)

Other forms of this molecule

Babam1 [cytosol]

Inferred From

BABAM1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001006965.1, XP_006252919.1

ENSEMBL

ENSRNOT00000022938, ENSRNOP00000022938

PRO

Q5XIJ6

RGD

1359516

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