Reactome | Ctsz [COPII-coated ER to Golgi transport vesicle]

Ctsz [COPII-coated ER to Golgi transport vesicle]

Stable Identifier

R-RNO-5689727

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

COPII-coated ER to Golgi transport vesicle

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSZ, Q9R1T3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPII-mediated vesicle transport (Rattus norvegicus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPII-mediated vesicle transport (Rattus norvegicus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
      - CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
      - Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
      - Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9R1T3

Gene Names

Ctsz

Reference Genes

BioGPS Gene:252929 Ctsz

ENSEMBL:ENSRNOG00000050697

ENSEMBL:ENSRNOG00000050697 Ctsz

KEGG Gene (Rattus norvegicus):252929 Ctsz

Monarch:252929 Ctsz

NCBI Gene:252929 Ctsz

Reference Transcript

RefSeq:NM_183330.1 Ctsz

Other Identifiers

10940594

1370885_at

17882637

17882638

252929

5940837

6030544

6322659

A_44_P428420

GE13088

GO:0003824

GO:0006508

GO:0008234

GO:0016787

GO:0140096

PH_rn_0015028

rc_AA818798_at

rc_AA851184_s_at

Participates

as a member of

glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)

Other forms of this molecule

Ctsz [Golgi lumen]

Ctsz [lysosomal lumen]

Ctsz [plasma membrane]

Ctsz [specific granule lumen]

Ctsz [extracellular region]

Ctsz [ficolin-1-rich granule lumen]

Ctsz [endoplasmic reticulum-Golgi intermediate compartment membrane]

Ctsz [endoplasmic reticulum lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

RefSeq

NP_899159.1

Ensembl

ENSRNOP00000066523, ENSRNOG00000050697, ENSRNOT00000072069

PRO

Q9R1T3

RGD

708479

Cite Us!