Reactome | GRIA1 [ER to Golgi transport vesicle membrane]

GRIA1 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-RNO-5689810

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

P19490

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPII-mediated vesicle transport (Rattus norvegicus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPII-mediated vesicle transport (Rattus norvegicus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P19490 Gria1

Gene Names

Gria1, Glur1

Chain

signal peptide:1-18, chain:19-907

Reference Genes

BioGPS Gene:50592 Gria1

ENSEMBL:ENSRNOG00000045816.4 Gria1

ENSEMBL:ENSRNOG00055029717 Gria1

ENSEMBL:ENSRNOG00060022487 Gria1

ENSEMBL:ENSRNOG00065006524 Gria1

KEGG Gene (Rattus norvegicus):50592 Gria1

Monarch:50592 Gria1

NCBI Gene:50592 Gria1

UCSC:P19490 Gria1

Reference Transcript

RefSeq:NM_031608.1 Gria1

Other Identifiers

10733723

1371013_at

17646019

50592

6505864

6610380

A_43_P15761

A_64_P013212

GE21806

GO:0004970

GO:0004971

GO:0005215

GO:0005216

GO:0005576

GO:0005768

GO:0005783

GO:0005886

GO:0006811

GO:0007268

GO:0007416

GO:0007616

GO:0008021

GO:0008328

GO:0009986

GO:0014069

GO:0015276

GO:0016020

GO:0016192

GO:0022890

GO:0023052

GO:0030425

GO:0030672

GO:0031410

GO:0031623

GO:0032281

GO:0032590

GO:0032591

GO:0034220

GO:0034330

GO:0035235

GO:0036477

GO:0038023

GO:0043005

GO:0043025

GO:0043197

GO:0043226

GO:0044297

GO:0044308

GO:0044309

GO:0045202

GO:0045211

GO:0048856

GO:0050877

GO:0055037

GO:0055065

GO:0055085

GO:0060076

GO:0060078

GO:0060089

GO:0060292

GO:0071242

GO:0097060

GO:0098793

GO:0098794

GO:0098839

GO:0098978

GO:0099505

GO:0099507

GO:0099544

GO:0099566

GO:0099583

GO:1904315

M36418_s_at

PH_rn_0012397

S56679_s_at

X17184_at

Participates

as a component of

CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

GRIA1 [endoplasmic reticulum membrane]

GRIA1 [endocytic vesicle membrane]

p-S849-Gria1 [plasma membrane]

GRIA1 [plasma membrane]

Gria1 [plasma membrane]

Inferred From

GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_113796.1

Ensembl

ENSRNOT00000081136, ENSRNOG00000045816, ENSRNOP00000074119, ENSRNOP00000064722, ENSRNOT00000071615

ZINC target

P19490

PRO

P19490

RGD

621531

PDB

3SAJ, 8AYO, 8AYN, 7OCA, 2AWW, 7QHB, 2G2L, 7OCC, 7QHH, 8C2H, 7OCD, 6QKC, 7OCE, 8P3T, 8P3U, 7OCF, 8C2I, 6QKZ, 6NJL, 8AYL, 8C1P, 8P3W, 8C1Q, 8P3V, 8AYM, 6NJN

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q71RJ2	2	Cacng2 [endocytic vesicle membrane] (R-RNO-416846) Cacng2 [plasma membrane] (R-RNO-210375)	0.858	7
UniProt:P19491 Gria2	4	Gria2 [plasma membrane] (R-RNO-9022384) phospho-p-S880-GRIA2 [plasma membrane] (R-RNO-3004500) GRIA2 [endocytic vesicle membrane] (R-RNO-3004487) GRIA2 [plasma membrane] (R-RNO-3004502)	0.688	3
UniProt:P31016 Dlg4	3	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847) Dlg4 [plasma membrane] (R-RNO-9612601)	0.649	5
UniProt:P19490 Gria1	7	GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811) GRIA1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) GRIA1 [endoplasmic reticulum membrane] (R-RNO-5689460) GRIA1 [endocytic vesicle membrane] (R-RNO-3004479) p-S849-Gria1 [plasma membrane] (R-RNO-9620442) GRIA1 [plasma membrane] (R-RNO-3004495) Gria1 [plasma membrane] (R-RNO-9620440)	0.623	2
UniProt:Q5FVC2	1	Arhgef2 [cytosol] (R-RNO-195101)	0.576	4
UniProt:P11275 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-RNO-432796) phospho-p-T286-CAMK2A [nucleoplasm] (R-RNO-444797) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-RNO-4332334) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-RNO-416999) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.567	4
UniProt:Q5BJU5	3	Cnih2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689781) Cnih2 [ER to Golgi transport vesicle membrane] (R-RNO-5689780) Cnih2 [endoplasmic reticulum membrane] (R-RNO-5689442)	0.499	3
UniProt:B2GV74 B2GV74			0.499	2
UniProt:P70569	1	MYO5B [cytoplasmic vesicle membrane] (R-RNO-2028712)	0.499	2
UniProt:P10608	5	phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869143) Adrb2 [endosome membrane] (R-RNO-6783036) Adrb2 [endosome membrane] (R-RNO-6783066) phospho-Adrb2 [plasma membrane] (R-RNO-8852158) Adrb2 [plasma membrane] (R-RNO-390647)	0.499	3

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