Reactome | Gria1 [ER to Golgi transport vesicle membrane]

Gria1 [ER to Golgi transport vesicle membrane]

Stable Identifier

R-RNO-5689810

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

GRIA1, P19490

Locations in the PathwayBrowser

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Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Asparagine N-linked glycosylation (Rattus norvegicus)
    - Transport to the Golgi and subsequent modification (Rattus norvegicus)
      - ER to Golgi Anterograde Transport (Rattus norvegicus)
        
        COPII-mediated vesicle transport (Rattus norvegicus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - ER to Golgi Anterograde Transport (Rattus norvegicus)
    - COPII-mediated vesicle transport (Rattus norvegicus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - CSNK1D phosphorylates SEC23 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - Nucleotide exchange on RAB1 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
      - Vesicle budding (Rattus norvegicus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)
        
        Gria1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P19490 Gria1

Gene Names

Gria1, Glur1

Chain

signal peptide:1-18, chain:19-907

Reference Genes

BioGPS Gene:50592 Gria1

KEGG Gene (Rattus norvegicus):50592 Gria1

Monarch:50592 Gria1

NCBI Gene:50592 Gria1

UCSC:P19490 Gria1

Reference Transcript

RefSeq:NM_031608.1 Gria1

Participates

as a component of

CNIH2,3:GRIA1 [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

p-S849-Gria1 [plasma membrane]

Gria1 [plasma membrane]

Gria1 [endocytic vesicle membrane]

Gria1 [endoplasmic reticulum-Golgi intermediate compartment membrane]

Gria1 [endoplasmic reticulum membrane]

Gria1 [plasma membrane]

Inferred From

GRIA1 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_113796.1

ZINC target

P19490

PRO

P19490

GlyGen

P19490

RGD

621531

PDB

6NJN, 7OCE, 2AWW, 7OCC, 6NJL, 6QKZ, 7OCD, 7OCF, 6QKC, 7OCA, 2G2L, 3SAJ

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q71RJ2	1	Cacng2 [plasma membrane] (R-RNO-210375)	0.858	7
UniProt:P19491 Gria2	4	Gria2 [plasma membrane] (R-RNO-9022384) phospho-Gria2 [plasma membrane] (R-RNO-3004500) Gria2 [endocytic vesicle membrane] (R-RNO-3004487) Gria2 [plasma membrane] (R-RNO-3004502)	0.688	3
UniProt:P31016 Dlg4	2	Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [plasma membrane] (R-RNO-9612601)	0.649	5
UniProt:P19490 Gria1	7	p-S849-Gria1 [plasma membrane] (R-RNO-9620442) Gria1 [plasma membrane] (R-RNO-9620440) Gria1 [endocytic vesicle membrane] (R-RNO-3004479) Gria1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811) Gria1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) Gria1 [endoplasmic reticulum membrane] (R-RNO-5689460) Gria1 [plasma membrane] (R-RNO-3004495)	0.623	2
UniProt:Q5FVC2	1	Arhgef2 [cytosol] (R-RNO-195101)	0.576	4
UniProt:P11275 Camk2a	5	phospho-Camk2a [plasma membrane] (R-RNO-432796) phospho-Camk2a [nucleoplasm] (R-RNO-444797) phospho-Camk2a [cytosol] (R-RNO-4332334) Camk2a [cytosol] (R-RNO-9611390) p-T286-Camk2a [cytosol] (R-RNO-9618632)	0.567	4
UniProt:Q5BJU5	3	Cnih2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689781) Cnih2 [ER to Golgi transport vesicle membrane] (R-RNO-5689780) Cnih2 [endoplasmic reticulum membrane] (R-RNO-5689442)	0.499	3
UniProt:B2GV74	1	Klc2 [cytosol] (R-RNO-983191)	0.499	2
UniProt:P70569	1	Myo5b [cytoplasmic vesicle membrane] (R-RNO-2028712)	0.499	2
UniProt:P10608	5	phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869143) Adrb2 [endosome membrane] (R-RNO-6783036) Adrb2 [endosome membrane] (R-RNO-6783066) phospho-Adrb2 [plasma membrane] (R-RNO-8852158) Adrb2 [plasma membrane] (R-RNO-390647)	0.499	3

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