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Syk [cytosol]
Stable Identifier
R-RNO-58268
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
SYK, Q64725
Locations in the PathwayBrowser
Expand all
Hemostasis (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
Binding of Syk tyrosine kinase (Rattus norvegicus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
GPVI stimulates PI3K beta, gamma (Rattus norvegicus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
PLC gamma 2-mediated PIP2 hydrolysis (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Platelet Aggregation (Plug Formation) (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
SYK autophosphorylates at the activated BCR (Rattus norvegicus)
Antigen:p-BCR:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK binds the activated BCR (Rattus norvegicus)
Antigen:p-BCR:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
FLT3 signaling through SRC family kinases (Rattus norvegicus)
Active FLT3 binds to SYK (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
active FLT3:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin-2 signaling (Rattus norvegicus)
SYK binds IL2RB (Rattus norvegicus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK is a substrate for JAK1 (Rattus norvegicus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL ubiquitinates PI3K (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
FYN-like kinases [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
FYN-like kinases [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
FYN-like kinases [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
FYN-like kinases [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
Dectin-2 family (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
Phosphorylation of SYK (Rattus norvegicus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Recruitment of SYK to p-DAP12 (Rattus norvegicus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
FCGR activation (Rattus norvegicus)
Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Integrin signaling (Rattus norvegicus)
SYK activation by SRC (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
Syk [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q64725 Syk
Gene Names
Syk
Chain
chain:1-629
Reference Genes
BioGPS Gene:25155 Syk
KEGG Gene (Rattus norvegicus):25155 Syk
Monarch:25155 Syk
NCBI Gene:25155 Syk
Reference Transcript
RefSeq:NM_012758.1 Syk
Participates
as an input of
p-Y7-CLEC1B dimer:PDPN binds SYK (Rattus norvegicus)
SYK binds to integrin alphaIIb beta3 (Rattus norvegicus)
Active FLT3 binds to SYK (Rattus norvegicus)
SYK binds IL2RB (Rattus norvegicus)
SYK binds to p-Y65,Y76-FCER1G (Rattus norvegicus)
Recruitment of SYK to phosphorylated ITAMs (Rattus norvegicus)
Recruitment of SYK to p-FCERI gamma subunit (Rattus norvegicus)
Recruitment of SYK to p-DAP12 (Rattus norvegicus)
SYK binds the activated BCR (Rattus norvegicus)
Binding of Syk tyrosine kinase (Rattus norvegicus)
as a component of
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Rattus norvegicus)
active FLT3:SYK [plasma membrane] (Rattus norvegicus)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Rattus norvegicus)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:SYK [plasma membrane] (Rattus norvegicus)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Rattus norvegicus)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Rattus norvegicus)
as a candidate of
FYN-like kinases [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-Syk [cytosol]
phospho-Syk [plasma membrane]
p-317Y,519Y,520Y-Syk [cytosol]
Syk [cytosol]
phospho-Syk [cytosol]
phospho-Syk [cytosol]
Inferred From
SYK [cytosol]
(Homo sapiens)
Cross References
ZINC - Investigational
KSYK_RAT
RefSeq
NP_036890.1
ZINC - Metabolites
KSYK_RAT
ZINC - World Drugs
KSYK_RAT
IntEnz
2.7.10.2
ZINC - Substances
KSYK_RAT
ZINC target
Q64725
ZINC - Biogenic
KSYK_RAT
PRO
Q64725
ZINC - Predictions - Purchasable
KSYK_RAT
RGD
3796
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