Phosphorylation of PLCgamma by Netrin-1

Stable Identifier
R-RNO-622372
Type
Reaction [omitted]
Species
Rattus norvegicus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of PLCgamma by Netrin-1
Netrin-1-DCC mediated signaling rapidly phosphorylates PLCgamma. Netrin-1 mediated PLC activation depends on recruitment of PITPalpha to DCC. Stimulation of PLC signaling and hydrolysis of PIP2 by netrin-1 in neurons is time-dependent, with a maximal activity observed within 15 min of netrin-1 stimulation.
Literature References
PubMed ID Title Journal Year
16321979 DCC-dependent phospholipase C signaling in netrin-1-induced neurite elongation

Ren, XR, Xiong, WC, Xie, Y, Mei, L, Hong, Y, Ackerman, S, Ma, XY

J Biol Chem 2006
Participants
Input
Output
This event is regulated
Positively by
Regulator
Netrin-1:DCC [plasma membrane] (Rattus norvegicus)
Orthologous Events
Phosphorylation of PLCgamma by Netrin-1 (Homo sapiens)
Authored
Garapati, P V  (2010-04-23)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2010-04-23)
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