Reactome | Arrb2 [cytosol]

Arrb2 [cytosol]

Stable Identifier

R-RNO-6783000

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

PolyUb-ARRB2, P29067

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Deubiquitination (Rattus norvegicus)
    - Ub-specific processing proteases (Rattus norvegicus)
      - USP33 deubiquitinates CCP110,ARRB (Rattus norvegicus)
        
        USP33:PolyUb-CCP110,PolyUb-ARRB1,PolyUb-ARRB2 [cytosol] (Rattus norvegicus)
        
        PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Rattus norvegicus)
        
        Arrb2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P29067

Gene Names

Arrb2

Reference Genes

BioGPS Gene:25388 Arrb2

ENSEMBL:ENSRNOG00000019308

KEGG Gene (Rattus norvegicus):25388 Arrb2

Monarch:25388 Arrb2

NCBI Gene:25388 Arrb2

UCSC:P29067 Arrb2

Reference Transcript

RefSeq:NM_012911.1 Arrb2

Participates

as a member of

PolyUb-CCP110, PolyUb-ARRB2,(PolyUb-ARRB1) [cytosol] (Rattus norvegicus)

Other forms of this molecule

Arrb2 [endocytic vesicle membrane]

Arrb2 [cytosol]

Inferred From

PolyUb-ARRB2 [cytosol] (Homo sapiens)

Modified Residues

Name

ubiquitinylated lysine (PolyUb [cytosol]) at unknown position

Modification

PolyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_037043.1

PRO

P29067

RGD

2157

PDB

8J9K, 6K3F

HMDB Protein

HMDBP14510

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00987 MDM2	11	PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) MDM2 [plasma membrane] (R-HSA-416843) MDM2 [endocytic vesicle membrane] (R-HSA-416849) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [cytosol] (R-HSA-198644) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.631	4
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.524	2
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.524	2
UniProt:P29067	3	Arrb2 [endocytic vesicle membrane] (R-RNO-9910881) Arrb2 [cytosol] (R-RNO-6783000) Arrb2 [cytosol] (R-RNO-416464)	0.512	3
UniProt:P49187	3	MAPK10 [cytosol] (R-RNO-450352) phospho-p-T221,Y223-MAPK10 [cytosol] (R-RNO-450214) phospho-p-T221,Y223-MAPK10 [nucleoplasm] (R-RNO-450311)	0.508	3

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