Reactome | phospho-Il10ra [plasma membrane]

phospho-Il10ra [plasma membrane]

Stable Identifier

R-RNO-6784810

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

p-Y446-IL10RA, G3V830

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-10 signaling (Rattus norvegicus)
      - IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
      - STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
      - p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
      - p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Il10ra [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:G3V830

Gene Names

Il10ra

Reference Genes

BioGPS Gene:117539 Il10ra

ENSEMBL:ENSRNOG00000016308

ENSEMBL:ENSRNOG00000016308.5 Il10ra

KEGG Gene (Rattus norvegicus):117539 Il10ra

Monarch:117539 Il10ra

NCBI Gene:117539 Il10ra

Reference Transcript

Other Identifiers

10916973

117539

1385572_at

1387728_at

17851994

5832896

5922187

6007104

6022136

6028454

6125812

6188712

6204348

6261899

6377814

6404476

A_44_P763036

GE1298659

GE15739

GO:0004920

GO:0005515

GO:0005829

GO:0005886

GO:0006914

GO:0006954

GO:0010507

GO:0016192

GO:0016324

GO:0022600

GO:0023052

GO:0046427

GO:0050728

GO:0060089

GO:0060729

GO:0070086

ILMN_1350106

Participates

as a component of

p-Y-IL10RA:p-Y-JAK1 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Il10ra [plasma membrane]

phospho-Il10ra [plasma membrane]

Inferred From

p-Y-IL10RA [plasma membrane] (Homo sapiens)

p-Y446-IL10RA [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 446 (in Homo sapiens)

Coordinate

446

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006242926.1, NP_476541.2

Ensembl

ENSRNOG00000016308, ENSRNOT00000021926, ENSRNOP00000021926

RGD

620138