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Pten [nucleoplasm]
Stable Identifier
R-RNO-6807264
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
MonoUb-K13,K289-PTEN, O54857
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN localization (Rattus norvegicus)
Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)
Pten [nucleoplasm] (Rattus norvegicus)
USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
Pten [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:O54857
Gene Names
Pten
Reference Genes
BioGPS Gene:50557 Pten
ENSEMBL:ENSRNOG00000020723
KEGG Gene (Rattus norvegicus):50557 Pten
Monarch:50557 Pten
NCBI Gene:50557 Pten
Reference Transcript
RefSeq:NM_031606.1 Pten
Other Identifiers
10714832
1370112_at
17625048
50557
5727661
5743400
5907266
5984725
6014919
6022657
6032398
6049019
6071241
6106513
6332649
6340362
6361500
6452353
6487127
6508687
6598931
6740919
A_43_P12611
GE13188
GO:0000003
GO:0000278
GO:0000902
GO:0001525
GO:0001933
GO:0002376
GO:0002902
GO:0003674
GO:0004438
GO:0004721
GO:0004722
GO:0004725
GO:0005161
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006470
GO:0006629
GO:0006810
GO:0006950
GO:0007009
GO:0007049
GO:0007155
GO:0007165
GO:0007267
GO:0007270
GO:0007399
GO:0007416
GO:0007417
GO:0007507
GO:0007568
GO:0007584
GO:0007611
GO:0007613
GO:0007626
GO:0008138
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0008285
GO:0009056
GO:0009058
GO:0009410
GO:0009749
GO:0009898
GO:0010033
GO:0010035
GO:0010043
GO:0010628
GO:0010666
GO:0010719
GO:0010975
GO:0010977
GO:0010997
GO:0014065
GO:0014070
GO:0014823
GO:0016192
GO:0016311
GO:0016314
GO:0016324
GO:0016477
GO:0016605
GO:0016787
GO:0016791
GO:0019899
GO:0019901
GO:0021542
GO:0021700
GO:0021955
GO:0022607
GO:0030154
GO:0030165
GO:0030336
GO:0030534
GO:0031175
GO:0031642
GO:0031647
GO:0032228
GO:0032286
GO:0032355
GO:0032535
GO:0032869
GO:0033032
GO:0033137
GO:0033198
GO:0033555
GO:0034330
GO:0034641
GO:0035176
GO:0035255
GO:0035335
GO:0035749
GO:0036294
GO:0040007
GO:0040011
GO:0042254
GO:0042711
GO:0042802
GO:0042995
GO:0043005
GO:0043065
GO:0043066
GO:0043197
GO:0043220
GO:0043226
GO:0043491
GO:0043542
GO:0044281
GO:0044320
GO:0045211
GO:0045471
GO:0045475
GO:0045666
GO:0045736
GO:0045786
GO:0045792
GO:0046621
GO:0046685
GO:0046855
GO:0046856
GO:0048008
GO:0048646
GO:0048679
GO:0048681
GO:0048738
GO:0048853
GO:0048854
GO:0048856
GO:0048870
GO:0050680
GO:0050765
GO:0050771
GO:0050821
GO:0050877
GO:0051091
GO:0051548
GO:0051717
GO:0051726
GO:0051800
GO:0051895
GO:0051896
GO:0051898
GO:0055085
GO:0060024
GO:0060044
GO:0060070
GO:0060074
GO:0060101
GO:0060134
GO:0060179
GO:0060291
GO:0060292
GO:0060341
GO:0060736
GO:0060997
GO:0061002
GO:0061024
GO:0070373
GO:0070374
GO:0071257
GO:0071361
GO:0071456
GO:0090071
GO:0090344
GO:0090394
GO:0097105
GO:0097107
GO:0099524
GO:0106306
GO:0106307
GO:1900425
GO:1901017
GO:1902807
GO:1903690
GO:1903984
GO:1904668
GO:1904706
GO:1990090
GO:1990314
GO:1990381
GO:1990782
GO:2000060
GO:2000134
GO:2000272
GO:2000463
GO:2000808
GO:2001235
PH_rn_0012064
rc_AA963447_at
Participates
as an input of
USP7 deubiquitinates monoubiquitinated PTEN (Rattus norvegicus)
as an output of
Monoubiquitinated PTEN translocates to the nucleus (Rattus norvegicus)
Other forms of this molecule
Pten [cytosol]
Pten [nucleoplasm]
Pten [cytosol]
Pten [cytosol]
Pten [cytosol]
Pten [cytosol]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
phospho-Pten [cytosol]
Pten [nucleoplasm]
Pten [cytosol]
Inferred From
MonoUb-K13,K289-PTEN [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (ubiquitin [nucleoplasm]) at 13 (in Homo sapiens)
Coordinate
13
Modification
Ub [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (ubiquitin [nucleoplasm]) at 289 (in Homo sapiens)
Coordinate
289
Modification
Ub [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_113794.1
Ensembl
ENSRNOT00000028143
,
ENSRNOG00000020723
,
ENSRNOP00000028143
RGD
61995
PDB
2K20
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31016 Dlg4
3
Dlg4 [endocytic vesicle membrane]
(R-RNO-416847)
Dlg4 [cytosol]
(R-RNO-6794248)
Dlg4 [plasma membrane]
(R-RNO-9612601)
0.612
5
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