Reactome | Ints5 [nucleoplasm]

Ints5 [nucleoplasm]

Stable Identifier

R-RNO-6807418

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

INTS5, D3ZTW1

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Rattus norvegicus)

- RNA Polymerase II Transcription (Rattus norvegicus)
  - RNA polymerase II transcribes snRNA genes (Rattus norvegicus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
    - Integrator complex processes the 3' end of snRNA (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Rattus norvegicus)
      - Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Rattus norvegicus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Rattus norvegicus)
        
        Integrator [nucleoplasm] (Rattus norvegicus)
        
        Ints5 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZTW1

Gene Names

Ints5

Reference Genes

BioGPS Gene:309200 Ints5

ENSEMBL:ENSRNOG00000026005

KEGG:rno:309200 Ints5

Monarch:309200 Ints5

NCBI Entrez Gene:309200 Ints5

UCSC:D3ZTW1 Ints5

Reference Transcript

RefSeq:NM_001107576.1 Ints5

Other Identifiers

10713703

1373562_at

17623809

309200

5779549

5964542

6121934

6176666

6275381

A_44_P525151

GE1216694

GE18994

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0016073

GO:0016180

GO:0032039

GO:0034472

GO:0160232

GO:0160240

ILMN_1369046

PH_rn_0010384

rc_AI013101_at

Participates

as a component of

Integrator [nucleoplasm] (Rattus norvegicus)

Inferred From

INTS5 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001101046.1

ENSEMBL

ENSRNOP00000032158, ENSRNOT00000036115, ENSRNOG00000026005

RGD

1309370