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phospho-Cdk6 [nucleoplasm]
Stable Identifier
R-RNO-69628
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
p-T177-CDK6, F1MA87
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle, Mitotic (Rattus norvegicus)
Mitotic G1 phase and G1/S transition (Rattus norvegicus)
G1 Phase (Rattus norvegicus)
Cyclin D associated events in G1 (Rattus norvegicus)
CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3:CDK6 inhibitors (CCND3) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
Drug-mediated inhibition of CDK4/CDK6 activity (Rattus norvegicus)
CDK6 inhibitors bind CDK6 (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2:CDK6 inhibitors (CCND2) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3:CDK6 inhibitors (CCND3) [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
phospho-Cdk6 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:F1MA87
Gene Names
Cdk6
Reference Genes
BioGPS Gene:114483 Cdk6
ENSEMBL:ENSRNOG00000009258
ENSEMBL:ENSRNOG00000009258.7 Cdk6
KEGG Gene (Rattus norvegicus):114483 Cdk6
Monarch:114483 Cdk6
NCBI Gene:114483 Cdk6
Reference Transcript
RefSeq:XM_008762679.2 Cdk6
RefSeq:XM_006236020.3 Cdk6
RefSeq:NM_001191861.1 Cdk6
RefSeq:XM_006236021.2 Cdk6
RefSeq:XM_006236019.3 Cdk6
Other Identifiers
10860765
114483
17789441
5749379
5757612
5799219
5817484
5864473
6030453
6204281
6278736
6292282
6301967
6418670
6526115
6569250
A_44_P405071
A_64_P113443
GE1129488
GO:0000122
GO:0002244
GO:0002376
GO:0003824
GO:0004672
GO:0004693
GO:0005524
GO:0006351
GO:0006355
GO:0006468
GO:0007219
GO:0010628
GO:0016301
GO:0016740
GO:0023052
GO:0030097
GO:0030154
GO:0033077
GO:0036211
GO:0042127
GO:0043697
GO:0048856
GO:0060218
GO:0097132
GO:0140096
GO:1902036
ILMN_1374074
PH_rn_0016305
PH_rn_0019252
Participates
as a component of
p-T177-CDK6:CCND3 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND2 [nucleoplasm] (Rattus norvegicus)
p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
as a candidate of
p-T172-CDK4,p-T177-CDK6 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
Cdk6 [cytosol]
Cdk6 [nucleoplasm]
Inferred From
p-T177-CDK6 [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-threonine at 177 (in Homo sapiens)
Coordinate
177
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
XP_006236083.1
,
XP_006236081.1
,
NP_001178790.1
,
XP_008760901.1
,
XP_006236082.1
Ensembl
ENSRNOG00000009258
,
ENSRNOT00000012597
,
ENSRNOP00000012597
RGD
621121
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