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Ripk2 [cytosol]
Stable Identifier
R-RNO-706483
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Ub-209-RIPK2, G3V783
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-17 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
K63 polyubiquitinated RIP2 associates with the TAK1 complex (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
RIP2 is K63 polyubiquitinated (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
TAK1 is activated (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:TAK1 complex [plasma membrane] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
MAP kinase activation (Rattus norvegicus)
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 (Rattus norvegicus)
Activated TAK1 phosphorylates MKK4/MKK7 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
activated TAK1 mediates p38 MAPK activation (Rattus norvegicus)
activated human TAK1 phosphorylates MKK3/MKK6 (Rattus norvegicus)
Activated TAK complexes [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO:activated TAK1 complex [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ovarian tumor domain proteases (Rattus norvegicus)
TNFAIP3 (A20) deubiquitinates RIP2 (Rattus norvegicus)
PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO [cytosol] (Rattus norvegicus)
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Ripk2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:G3V783
Gene Names
Ripk2
Reference Genes
BioGPS Gene:362491 Ripk2
ENSEMBL:ENSRNOG00000009389
ENSEMBL:ENSRNOG00000009389.6 Ripk2
KEGG Gene (Rattus norvegicus):362491 Ripk2
Monarch:362491 Ripk2
NCBI Gene:362491 Ripk2
Reference Transcript
RefSeq:NM_001191865.1 Ripk2
Other Identifiers
10875656
1381279_at
1394527_at
17806037
362491
5688986
5833342
5840244
6028851
6142471
6228862
6298635
6488027
6493593
6526828
6531710
6553907
6633117
6705683
6720747
A_43_P18344
A_44_P811606
GE1227937
GE1262994
GE1305646
GO:0001961
GO:0002250
GO:0002376
GO:0002827
GO:0003824
GO:0004672
GO:0004674
GO:0005102
GO:0005524
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0006468
GO:0006914
GO:0006915
GO:0007155
GO:0007249
GO:0007254
GO:0010800
GO:0012501
GO:0016740
GO:0019221
GO:0023052
GO:0030154
GO:0030274
GO:0031398
GO:0031663
GO:0031982
GO:0032722
GO:0032729
GO:0032731
GO:0032743
GO:0032755
GO:0032760
GO:0032874
GO:0032991
GO:0033080
GO:0033092
GO:0033138
GO:0034134
GO:0034142
GO:0035591
GO:0035739
GO:0036211
GO:0042098
GO:0042742
GO:0042802
GO:0042803
GO:0042981
GO:0043065
GO:0043123
GO:0043226
GO:0043330
GO:0045087
GO:0045627
GO:0046330
GO:0048856
GO:0050700
GO:0050731
GO:0050830
GO:0050852
GO:0051260
GO:0051403
GO:0060090
GO:0060907
GO:0065003
GO:0070371
GO:0070374
GO:0070427
GO:0070431
GO:0070555
GO:0070671
GO:0070673
GO:0071222
GO:0071223
GO:0071224
GO:0071225
GO:0089720
GO:0098542
GO:0098792
GO:0140096
GO:1902523
GO:1904417
GO:2000563
ILMN_1352868
ILMN_1365904
PH_rn_0017092
Participates
as a component of
PAMP:NOD oligomer:K63-Ub-RIP2 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Ripk2 [cytosol]
Inferred From
Ub-209-RIPK2 [cytosol]
(Homo sapiens)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 209 (in Homo sapiens)
Coordinate
209
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001178794.1
Ensembl
ENSRNOG00000009389
,
ENSRNOT00000012963
,
ENSRNOP00000012963
RGD
1309167
PDB
6GWM
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