Reactome | Uba52 [cytosol]

Uba52 [cytosol]

Stable Identifier

R-RNO-72363

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPS27A(77-156), P62986

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol (Rattus norvegicus)
        
        40S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Uba52 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P62986

Gene Names

Uba52

Reference Genes

BioGPS Gene:64156 UBIQ

ENSEMBL:ENSRNOG00000019971

ENSEMBL:ENSRNOG00000019974

ENSEMBL:ENSRNOG00000090524

KEGG:rno:64156 UBIQ

Monarch:64156 UBIQ

NCBI Gene:64156 UBIQ

UCSC:P62986 Uba52

Reference Transcript

Other Identifiers

10787544

1398754_at

17707146

6078928

6266531

64156

6492767

6502853

6638007

6685017

GO:0002181

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005737

GO:0005840

GO:0006412

GO:0015934

GO:0016567

GO:0017085

GO:0019941

GO:0022625

GO:0022626

GO:0031386

GO:0031625

GO:0045202

GO:0098556

GO:1990904

ILMN_1351207

PH_rn_0011321

rc_AA818888_at

Participates

as a component of

as an output of

UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin (Rattus norvegicus)

Other forms of this molecule

Uba52 [cytosol]

Uba52 [nucleoplasm]

Uba52 [cytosol]

Uba52 [nucleoplasm]

Uba52 [endoplasmic reticulum membrane]

Uba52 [cytosol]

Uba52 [mitochondrial outer membrane]

Uba52 [endosome membrane]

phospho-Uba52 [cytosol]

Uba52 [cytosol]

phospho-Uba52 [nucleoplasm]

Uba52 [cytosol]

Uba52 [mitochondrial outer membrane]

Uba52 [nucleoplasm]

Uba52 [endocytic vesicle membrane]

Inferred From

RPS27A(77-156) [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_063131755.1, NP_113875.1, XP_006252997.1, XP_008769368.1

ENSEMBL

ENSRNOP00000027073, ENSRNOT00000027073, ENSRNOG00000090524

PRO

P62986

GlyGen

P62986

RGD

68344

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