Reactome | Rpl36a [cytosol]

Rpl36a [cytosol]

Stable Identifier

R-RNO-72480

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL36A, P83883

Locations in the PathwayBrowser

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Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        RPL36A,RPL36AL [cytosol] (Rattus norvegicus)
        
        Rpl36a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P83883

Gene Names

Rpl36a

Reference Genes

BioGPS Gene:292964 Rpl36a

BioGPS Gene:81769 Rpl36a

CTD Gene:81769 Rpl36a

ENSEMBL:ENSRNOG00000011494

ENSEMBL:ENSRNOG00000011494.5 Rpl36a

ENSEMBL:ENSRNOG00000031022

ENSEMBL:ENSRNOG00000031315

ENSEMBL:ENSRNOG00000031315.3 Rpl36a

ENSEMBL:ENSRNOG00000032408

ENSEMBL:ENSRNOG00055009019

ENSEMBL:ENSRNOG00055014355

ENSEMBL:ENSRNOG00055032988

ENSEMBL:ENSRNOG00060005818

ENSEMBL:ENSRNOG00060020513

ENSEMBL:ENSRNOG00060032001

ENSEMBL:ENSRNOG00065006379

ENSEMBL:ENSRNOG00065006637

ENSEMBL:ENSRNOG00065030144

KEGG Gene (Rattus norvegicus):292964 Rpl36a

Monarch:292964 Rpl36a

Monarch:81769 Rpl36a

NCBI Gene:292964 Rpl36a

NCBI Gene:81769 Rpl36a

UCSC:P83883 Rpl36a

Reference Transcript

Other Identifiers

10735315

10770410

10934940

1371573_at

17647883

17873891

292964

5620734

5677245

5747695

5977583

6037134

6188279

6205823

6338853

6548921

6594301

6609207

6625443

6672135

6704880

81769

A_44_P278670

A_64_P085695

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0043226

ILMN_1368842

PH_rn_0002942

rc_AI177911_at

Participates

as a member of

RPL36A,RPL36AL [cytosol] (Rattus norvegicus)

Other forms of this molecule

Rpl36a [cytosol]

Inferred From

RPL36A [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_017456534.1, NP_112367.1, NP_001121537.1, XP_017458727.1, XP_017458726.1

Ensembl

ENSRNOG00000011494, ENSRNOT00000057222, ENSRNOP00000054048, ENSRNOG00000031315, ENSRNOP00000048003, ENSRNOT00000043171

PRO

P83883

RGD

621156, 1306640

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