Reactome | Rpl8 [cytosol]

Rpl8 [cytosol]

Stable Identifier

R-RNO-72490

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RPL8, P62919

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Rattus norvegicus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        80S ribosome [cytosol] (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)
- rRNA processing (Rattus norvegicus)
  - rRNA processing in the nucleus and cytosol (Rattus norvegicus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Rattus norvegicus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Rattus norvegicus)
        
        60S ribosomal complex [cytosol] (Rattus norvegicus)
        
        Rpl8 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P62919

Gene Names

Rpl8

Reference Genes

BioGPS Gene:26962 Rpl8

ENSEMBL:ENSRNOG00000032635

ENSEMBL:ENSRNOG00000048456

ENSEMBL:ENSRNOG00000048523

ENSEMBL:ENSRNOG00000068956

ENSEMBL:ENSRNOG00000068956.1 Rpl8

ENSEMBL:ENSRNOG00055026430

ENSEMBL:ENSRNOG00060027577

ENSEMBL:ENSRNOG00065030572

KEGG Gene (Rattus norvegicus):100360117 Rpl8

KEGG Gene (Rattus norvegicus):26962 Rpl8

Monarch:26962 Rpl8

NCBI Gene:26962 Rpl8

UCSC:P62919 Rpl8

Reference Transcript

Other Identifiers

10716060

10834406

10897394

1370327_at

1371305_at

17760140

17830336

17830341

26962

5641355

5679990

5683529

5771487

5783418

5830256

5892462

5924452

5927058

6091208

6097965

6148036

6331089

6443279

6447031

6497682

6568755

6598439

6683161

6695189

6700580

A_44_P308673

A_64_P084455

GE1275699

GE1303584

GO:0003723

GO:0003735

GO:0005198

GO:0005840

GO:0006412

GO:0015934

GO:0043226

ILMN_1369431

PH_rn_0004853

PH_rn_0024118

X62145cds_at

X62145cds_g_at

rc_AA892582_s_at

rc_AA899199_at

Participates

as a component of

Other forms of this molecule

Rpl8 [nucleoplasm]

Inferred From

RPL8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_002729189.1, XP_017450875.1, NP_001030088.2

Ensembl

ENSRNOP00000077291, ENSRNOG00000068956, ENSRNOT00000100252

PRO

P62919

RGD

619827

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