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CYLD [cytosol]
Stable Identifier
R-RNO-741420
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q66H62
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Rattus norvegicus)
Negative regulators of DDX58/IFIH1 signaling (Rattus norvegicus)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways (Rattus norvegicus)
NOD1/2 Signaling Pathway (Rattus norvegicus)
CYLD deubiquitinates NEMO (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ub-specific processing proteases (Rattus norvegicus)
CYLD deubiquitinates K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD mediated deubiquitination of DDX58 (RIG-I) (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CHUK, IKBKB phosphorylate RIPK1 at S25 (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63,Met1polyUb, p-S25-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNFα:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2/3:p-S-CHUK:p-S-IKBKB:IKBKG [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD hydrolyses K63polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD hydrolyses M1polyUb on RIPK1 within the TNFR1 complex (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC binds TNFR1 signaling complex (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
K63polyUb-RIPK1 is deubiquitinated (Rattus norvegicus)
RIPK1 deubiquitinases [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
MIB2 binds CYLD (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
MIB2:CYLD:UBE2D2 [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
MIB2 ubiquitinates CYLD at K338, K530 (Rattus norvegicus)
MIB2:CYLD:UBE2D2 [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
OPTN binds polyUb-RIPK1 within the TNFR1 complex (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
SPATA2:CYLD-bound LUBAC ubiquitinates RIPK1 at K627 within the TNFR1 signaling complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUb-RIPK1:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TBK1, IKBKE binds Met1-polyUb within the TNFR1 complex (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TBK1, IKBKE phosphorylate RIPK1 at T189 (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNFR1-induced NF-kappa-B signaling pathway (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Rattus norvegicus)
RIPK1 deubiquitinases [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUB-RIPK1:LUBAC:OPTN [plasma membrane] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:polyUb-RIPK1:LUBAC [plasma membrane] (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex (Rattus norvegicus)
RIPK1 deubiquitinases [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TNFR1-induced proapoptotic signaling (Rattus norvegicus)
TRADD:TRAF2:RIP1 complex binds FADD (Rattus norvegicus)
RIPK1 deubiquitinases [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
TRADD:TRAF2:RIP1 complex dissociates from the TNF-α:TNF-R1 complex. (Rattus norvegicus)
TNF-alpha:TNFR1:TRADD:p-T189,K63,M1polyUb-RIPK1:BIRC2,3,4:LUBAC:SPATA2:CYLD:TBK1,IKBKE [plasma membrane] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
CYLD [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q66H62
Reference Genes
BioGPS Gene:312937
ENSEMBL:ENSRNOG00000014048
KEGG Gene (Rattus norvegicus):312937
Monarch:312937
NCBI Gene:312937
Reference Transcript
RefSeq:NM_001017380.1
Participates
as a component of
CYLD:K63polyUb-TRAF2,K63polyUb-TRAF6,K63polyUb-RIPK1,K63polyUb-IKBKG [cytosol] (Rattus norvegicus)
CYLD:OPTN:polyUb-RIPK1:TNFR1 complex [plasma membrane] (Rattus norvegicus)
MIB2:CYLD:UBE2D2 [cytosol] (Rattus norvegicus)
CYLD:SPATA2:LUBAC [cytosol] (Rattus norvegicus)
as an input of
OPTN recruits CYLD to the TNFR1 complex (Rattus norvegicus)
CHUK, IKBKB phosphorylate CYLD at S418 (Rattus norvegicus)
MIB2 binds CYLD (Rattus norvegicus)
as a member of
RIPK1 deubiquitinases [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S418-CYLD [cytosol]
K48polyUb-K338, K530-CYLD [cytosol]
Inferred From
CYLD [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_001017380.1
PRO
Q66H62
RGD
1308346
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