Reactome | Grb2 [cytosol]

Grb2 [cytosol]

Stable Identifier

R-RNO-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

GRB2-1, P62994

Locations in the PathwayBrowser for interactor UniProt:Q13094 LCP2

Expand all

External Reference Information

External Reference

UniProt:P62994 Grb2

Gene Names

Grb2, Ash

Chain

chain:1-217

Reference Genes

BioGPS Gene:81504 Grb2

ENSEMBL:ENSRNOG00000003990.7 Grb2

ENSEMBL:ENSRNOG00055032965 Grb2

ENSEMBL:ENSRNOG00060019266 Grb2

ENSEMBL:ENSRNOG00065020618 Grb2

KEGG Gene (Rattus norvegicus):81504 Grb2

Monarch:81504 Grb2

NCBI Gene:81504 Grb2

Reference Transcript

RefSeq:NM_030846.2 Grb2

Other Identifiers

10749005

1368385_a_at

1368386_at

17663263

5810699

5907758

6003656

6112512

6176821

6348946

6533420

6674437

6728959

81504

A_43_P15304

A_64_P001804

GE1196334

GO:0001784

GO:0002376

GO:0005068

GO:0005091

GO:0005154

GO:0005168

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005886

GO:0005911

GO:0005938

GO:0007010

GO:0007165

GO:0007173

GO:0007265

GO:0008180

GO:0008286

GO:0008543

GO:0012506

GO:0014044

GO:0016020

GO:0016192

GO:0017124

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0023052

GO:0030036

GO:0030154

GO:0030674

GO:0030838

GO:0031410

GO:0031623

GO:0032991

GO:0035987

GO:0042552

GO:0042770

GO:0042802

GO:0043226

GO:0043408

GO:0043560

GO:0044877

GO:0046875

GO:0048009

GO:0048646

GO:0048856

GO:0050853

GO:0051219

GO:0060090

GO:0060670

GO:0065003

GO:0070436

GO:0071479

GO:0098772

GO:2000379

PH_rn_0011769

rc_AA801130_at

rc_AI170776_s_at

Participates

as a component of

as an input of

as an output of

PPTN11 dephosphorylates SPRY2 (Rattus norvegicus)

as a member of

Other forms of this molecule

Grb2 [cytosol]

Grb2 [plasma membrane]

Inferred From

GRB2-1 [cytosol] (Homo sapiens)

GRB2 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_110473.2

Ensembl

ENSRNOG00000003990, ENSRNOT00000095127, ENSRNOP00000080275

PRO

P62994

RGD

619758

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.822	5
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.78	5
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.688	3
UniProt:Q13094 LCP2	2	p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175) LCP2 [cytosol] (R-HSA-202306)	0.676	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.589	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	5
UniProt:O43426 SYNJ1	1	SYNJ1 [cytosol] (R-HSA-1604634)	0.558	2
UniProt:P35739 Ntrk1	7	Phosphorylated TrkA receptor [Golgi membrane] (R-RNO-189653) Ntrk1 [Golgi membrane] (R-RNO-189650) phospho-p-5Y-NTRK1-1 [endosome membrane] (R-RNO-190064) Phosphorylated TrkA receptor [plasma membrane] (R-RNO-181844) TrkA receptor [plasma membrane] (R-RNO-179526) NTRK1 [plasma membrane] (R-RNO-3008784) phospho-p-5Y-NTRK1 [plasma membrane] (R-RNO-3009413)	0.548	6
UniProt:Q9NZQ3 NCKIPSD	1	NCKIPSD [cytosol] (R-HSA-2197671)	0.544	2
UniProt:P18545 PDE6G	2	PDE6G [photoreceptor disc membrane] (R-HSA-52449) PDE6G [plasma membrane] (R-HSA-4085973)	0.527	2
UniProt:P21575 Dnm1	4	DNM1 [cytosol] (R-RNO-2213182) Dynamin 1 [plasma membrane] (R-RNO-941853) DNM1 [lysosomal membrane] (R-RNO-196150) DNM1 [plasma membrane] (R-RNO-177488)	0.524	3

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