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phospho-Irs2 [cytosol]
Stable Identifier
R-RNO-74774
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
p-Y-IRS2, F1MAL5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
RAS GEFs [plasma membrane] (Rattus norvegicus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to EPOR [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS activation (Rattus norvegicus)
Dissociation of IRS-P from insulin receptor (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Phosphorylation of IRS (Rattus norvegicus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
SOS-mediated signalling (Rattus norvegicus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Signal attenuation (Rattus norvegicus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Rattus norvegicus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Rattus norvegicus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
SOS-mediated signalling (Rattus norvegicus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Rattus norvegicus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
phospho-Irs2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:F1MAL5 Irs2
Gene Names
Irs2, rCG_43183
Reference Genes
BioGPS Gene:29376 Irs2
ENSEMBL:ENSRNOG00000023509.7 Irs2
KEGG Gene (Rattus norvegicus):29376 Irs2
Monarch:29376 Irs2
NCBI Gene:29376 Irs2
Reference Transcript
RefSeq:NM_001168633.1 Irs2
Other Identifiers
10789653
1371091_at
17709452
29376
5798836
6230232
6297423
6374596
6439561
6667142
6706549
AF050159_at
AF083418_at
AF087674_at
A_44_P400393
A_44_P503503
A_44_P684795
GE21356
GE21397
GE21404
GO:0002053
GO:0002376
GO:0002903
GO:0005068
GO:0005158
GO:0005829
GO:0005886
GO:0005975
GO:0006091
GO:0006629
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0012501
GO:0016477
GO:0019901
GO:0023052
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048856
GO:0048870
GO:0051897
GO:0055085
GO:0060090
GO:0141038
GO:1904692
PH_rn_0011366
PH_rn_0023785
Participates
as a component of
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Rattus norvegicus)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Rattus norvegicus)
Other forms of this molecule
p-Y-Irs2 [cytosol]
Irs2 [cytosol]
Irs2 [plasma membrane]
Irs2 [cytosol]
phospho-Irs2 [plasma membrane]
Inferred From
p-Y-IRS2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001162104.1
Ensembl
ENSRNOT00000032918
,
ENSRNOG00000023509
,
ENSRNOP00000036862
RGD
69316
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