Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Pik3ca [cytosol]
Stable Identifier
R-RNO-74787
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
PIK3CA, A0A0G2K344
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
RET signaling (Rattus norvegicus)
p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Hemostasis (Rattus norvegicus)
Cell surface interactions at the vascular wall (Rattus norvegicus)
Tie2 Signaling (Rattus norvegicus)
Interaction of Tie2 and p85 of PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85 bound to Tie2 [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Platelet activation, signaling and aggregation (Rattus norvegicus)
GPVI-mediated activation cascade (Rattus norvegicus)
PI3K alpha, beta, gamma convert PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, beta, gamma [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
CD28 bound PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
CD28:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K binds CD28 (Rattus norvegicus)
CD28:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Co-stimulation by ICOS (Rattus norvegicus)
PI3K binds ICOS (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
ICOS:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Downstream TCR signaling (Rattus norvegicus)
PI3K bound to TRAT1 phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Recruitment of PI3K to plasma membrane (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
FLT3 Signaling (Rattus norvegicus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-2 family signaling (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
14-3-3 zeta binding allows recruitment of PI3K (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(S589)-Bc:14-3-3 zeta:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Interleukin receptor SHC signaling (Rattus norvegicus)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Regulation of signaling by CBL (Rattus norvegicus)
CBL ubiquitinates PI3K (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
K63polyUb-p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
K63polyUb-PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Rattus norvegicus)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85-containing Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
PI3K associates with phosphorylated GAB2 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Phosphorylation of PIP2 to PIP3 by PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K binds to p-6Y-SYK (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Phospholipid metabolism (Rattus norvegicus)
PI Metabolism (Rattus norvegicus)
Synthesis of PIPs at the plasma membrane (Rattus norvegicus)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Rattus norvegicus)
PIK3C(1) [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R2 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R3 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Rattus norvegicus)
PIK3(2) [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R2 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R3 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
Negative regulation of the PI3K/AKT network (Rattus norvegicus)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
CD28:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
ICOS:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activator:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
BDNF,NTF4:p-5Y-NTRK2:GRB2:GAB1:PIK3CA:PIK3R1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
CD28:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
ICOS:PI3K [plasma membrane] (Rattus norvegicus)
Class 1A PI3Ks [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
NTF3:p-5Y-NTRK3 homodimer:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K bound to TRAT [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC1,RAC2,RHOG activate PI3K (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC1:GTP,RAC2:GTP,RHOG:GTP:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
RAS:GTP binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p21 RAS:GTP:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Erythropoietin (Rattus norvegicus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K bound to EPOR [plasma membrane] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha, gamma [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
G alpha (q) inhibits PI3K alpha (Rattus norvegicus)
G-protein alpha (q/11):PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Nuclear Receptors (Rattus norvegicus)
ESR-mediated signaling (Rattus norvegicus)
Extra-nuclear estrogen signaling (Rattus norvegicus)
PI3K binds membrane-associated estrogen receptors (Rattus norvegicus)
ESRs:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PTK2 is recruited to methylated ESR1 (Rattus norvegicus)
Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Rattus norvegicus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Me260-ESR1:STRN:ESTG:MyrG-pY419 SRC:PI3K alpha [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by ALK (Rattus norvegicus)
Active ALK recruits PI3K (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K synthesizes PIP3 downstream of ALK (Rattus norvegicus)
Active ALK:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by EGFR (Rattus norvegicus)
GAB1 signalosome (Rattus norvegicus)
PI3K binds to EGF:EGFR:GRB2:GAB1 (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K converts phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3) (Rattus norvegicus)
EGF-like ligands:p-6Y-EGFR:GRB2:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by ERBB2 (Rattus norvegicus)
PI3K events in ERBB2 signaling (Rattus norvegicus)
Binding of PI3K to ERBB2:p-ERBB3 heterodimer (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Binding of PI3K to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Binding of PI3K to p-ERBB2:p-ERBB4 CYT-1 heterodimers (Rattus norvegicus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to GRB2:GAB1 in complex with phosphorylated heterodimer of ERBB2 and EGFR (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB3 (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIP2 to PIP3 conversion by PI3K bound to phosphorylated heterodimer of ERBB2 and ERBB4 CYT1 (Rattus norvegicus)
NRGs/EGFLs:p-ERBB4cyt1:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by ERBB4 (Rattus norvegicus)
PI3K events in ERBB4 signaling (Rattus norvegicus)
Binding of p85 subunit of PI3K (PIK3R1) to p-ERBB4cyt1 homodimers (Rattus norvegicus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Conversion of PIP2 into PIP3 by PI3K bound to p-ERBB4cyt1 homodimers (Rattus norvegicus)
PI3K:p-ERBB4cyt1 [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by FGFR (Rattus norvegicus)
Signaling by FGFR1 (Rattus norvegicus)
Downstream signaling of activated FGFR1 (Rattus norvegicus)
PI-3K cascade:FGFR1 (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR1-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by FGFR2 (Rattus norvegicus)
Downstream signaling of activated FGFR2 (Rattus norvegicus)
PI-3K cascade:FGFR2 (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR2-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by FGFR3 (Rattus norvegicus)
Downstream signaling of activated FGFR3 (Rattus norvegicus)
PI-3K cascade:FGFR3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR3-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by FGFR4 (Rattus norvegicus)
Downstream signaling of activated FGFR4 (Rattus norvegicus)
PI-3K cascade:FGFR4 (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
FGFR4-associated PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Insulin receptor (Rattus norvegicus)
Insulin receptor signalling cascade (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by LTK (Rattus norvegicus)
Active LTK receptor binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-5Y LTK dimer:ALKAL1,2:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by MET (Rattus norvegicus)
MET activates PI3K/AKT signaling (Rattus norvegicus)
MET bound PI3K generates PIP3 (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Phosphorylated GAB1 recruits PI3K to MET (Rattus norvegicus)
HGF:p-4Y-MET:p-5Y-GAB1, HGF:p-4Y-MET:GRB2-1:p-5Y-GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
PI3K/AKT activation (Rattus norvegicus)
Active IRS recruits PI3K to the plasma membrane and activates it (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K produces PIP3 and other phosphatidyl inositides (Rattus norvegicus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by PDGF (Rattus norvegicus)
Downstream signal transduction (Rattus norvegicus)
PI3-kinase binds to the active receptor (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K catalyses the phosphorylation of PIP2 to PIP3 (Rattus norvegicus)
PDGF:Phospho-PDGF receptor dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by SCF-KIT (Rattus norvegicus)
Direct recruitment of PI3K to p-KIT (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Indirect recruitment of PI3K to KIT via p(Y)-GAB2 (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Synthesis of PIP3 from PIP2 by PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT,PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
PI3K:p(Y)-GAB2:GRB2:p-SHP2:p-KIT complex [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
PI3K:p-KIT:sSCF dimer:p-KIT [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
IGF1R signaling cascade (Rattus norvegicus)
IRS-related events triggered by IGF1R (Rattus norvegicus)
IRS-mediated signalling (Rattus norvegicus)
PI3K Cascade (Rattus norvegicus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
PI3K-containing complexes [cytosol] (Rattus norvegicus)
Activated FGFR bound to PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Rattus norvegicus)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
p-AXL binds PI3K (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL:PI3K [plasma membrane] (Rattus norvegicus)
PI3K [cytosol] (Rattus norvegicus)
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 binds effectors at the plasma membrane (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 binds effectors at the plasma membrane (Rattus norvegicus)
RAC2 plasma membrane effectors [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Rattus norvegicus)
RAC2 plasma membrane effectors [cytosol] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
Pik3ca [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:A0A0G2K344 Pik3ca
Gene Names
Pik3ca
Chain
chain:1-1068
Reference Genes
BioGPS Gene:170911 Pik3ca
KEGG:rno:170911 Pik3ca
Monarch:170911 Pik3ca
NCBI Gene:170911 Pik3ca
UCSC:A0A0G2K344 Pik3ca
Reference Transcript
RefSeq:NM_133399.2 Pik3ca
Other Identifiers
10814726
10937594
1374232_at
1379041_at
1382366_at
1389143_at
1393499_at
170911
17737691
17876861
5621297
5665132
5670270
5681832
5684821
5707500
5801925
5839031
5847471
5880865
5921613
5951100
5955775
5981413
6051191
6070820
6078563
6086404
6086931
6097004
6120159
6131452
6157433
6206254
6219585
6230129
6288633
6294026
6300420
6329747
6423255
6424400
6435436
6440099
6547607
6586942
6604237
6623058
6699536
6727554
6729176
6734785
A_42_P562984
A_44_P156468
A_64_P066438
A_64_P073033
A_64_P130410
GE1148762
GE1182666
GE1206988
GE19439
GO:0001889
GO:0001932
GO:0003012
GO:0003013
GO:0003824
GO:0005942
GO:0005943
GO:0005975
GO:0006006
GO:0006091
GO:0006629
GO:0007010
GO:0008286
GO:0010468
GO:0012501
GO:0014065
GO:0014704
GO:0016301
GO:0016303
GO:0016310
GO:0016740
GO:0023052
GO:0030027
GO:0030036
GO:0030295
GO:0030835
GO:0032869
GO:0035004
GO:0035994
GO:0036211
GO:0038084
GO:0040014
GO:0043457
GO:0043491
GO:0043524
GO:0043560
GO:0046854
GO:0046934
GO:0048009
GO:0048015
GO:0048856
GO:0051897
GO:0055119
GO:0060612
GO:0071333
GO:0071464
GO:0086003
GO:0097009
GO:0098772
GO:0110053
GO:0141068
GO:1905477
GO:2000270
GO:2000811
ILMN_1352006
PH_rn_0006374
rc_AA964375_at
rc_AA997895_at
rc_AI030797_at
Participates
as an input of
Active FLT3:p-Y GRB10:PIK3R1 binds PIK3CA (Rattus norvegicus)
Active FLT3:GRB2:p-GAB2:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1binds PIK3CA (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA (Rattus norvegicus)
as a component of
active FLT3:p-Y GRB10:PI3K [plasma membrane] (Rattus norvegicus)
K63polyUb-PI3K alpha [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R3 [cytosol] (Rattus norvegicus)
PIK3CA:PIK3R2 [cytosol] (Rattus norvegicus)
Activated FGFR4:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR1:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR2:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
Activated FGFR3:p-FRS2:p-PTPN11:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
PI3K alpha [cytosol] (Rattus norvegicus)
NRG1/2:p-ERBB3:p-ERBB2:PI3K [plasma membrane] (Rattus norvegicus)
PIK3CA:PIK3R1 [cytosol] (Rattus norvegicus)
EGF:p-EGFR:p-ERBB2:GRB2:GAB1:PI3K [plasma membrane] (Rattus norvegicus)
as a member of
PI3K-catalytic subunit [cytosol] (Rattus norvegicus)
Other forms of this molecule
Pik3ca [cytosol]
Inferred From
PIK3CA [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_596890.2
ENSEMBL
ENSRNOT00000083720
,
ENSRNOP00000072496
,
ENSRNOG00000056371
IntEnz
2.7.1.153
PRO
A0A0G2K344
RGD
620916
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text