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Casp8 [cytosol]
Stable Identifier
R-RNO-75975
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
CASP8(217-374), Q9JHX4
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CLEC7A (Dectin-1) signaling (Rattus norvegicus)
CLEC7A/inflammasome pathway (Rattus norvegicus)
ASC binds Caspase-8 complex (Rattus norvegicus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Rattus norvegicus)
MALT1:active caspase-8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
MALT1:active caspase-8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Caspase-8 binds MALT (Rattus norvegicus)
MALT1:active caspase-8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Caspase-8 cleaves IL1B precursor (Rattus norvegicus)
MALT1 oligomers:active caspase-8:ASC [cytosol] (Rattus norvegicus)
MALT1:active caspase-8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRIF-mediated programmed cell death (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
Regulation of NF-kappa B signaling (Rattus norvegicus)
CASP8 cleaves N4BP1 at D424, D490 (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
N4BP1 binds IKBKG (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Programmed Cell Death (Rattus norvegicus)
Apoptosis (Rattus norvegicus)
Apoptotic execution phase (Rattus norvegicus)
Apoptotic cleavage of cellular proteins (Rattus norvegicus)
Caspase-mediated cleavage of cytoskeletal proteins (Rattus norvegicus)
Caspase mediated cleavage of vimentin at IDVD (259) (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Translocation of active caspase-8 to the mitochondrial membrane (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Caspase activation via extrinsic apoptotic signalling pathway (Rattus norvegicus)
Caspase activation via Death Receptors in the presence of ligand (Rattus norvegicus)
Caspase-8 processing within TLR4 complex (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Regulation by c-FLIP (Rattus norvegicus)
Caspase-8 and FLIP(L) processing at DISC (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Intrinsic Pathway for Apoptosis (Rattus norvegicus)
Activation, myristolyation of BID and translocation to mitochondria (Rattus norvegicus)
Caspase-8 activates BID by cleavage (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Regulated Necrosis (Rattus norvegicus)
RIPK1-mediated regulated necrosis (Rattus norvegicus)
Regulation of necroptotic cell death (Rattus norvegicus)
RIPK1 is cleaved by CASP8 (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
RIPK3 is cleaved by CASP8 (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Death Receptor Signaling (Rattus norvegicus)
TNF signaling (Rattus norvegicus)
Regulation of TNFR1 signaling (Rattus norvegicus)
RIPK1 is cleaved by CASP8 (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
TRAF1 is cleaved by caspases (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
active caspase-8 [cytosol] (Rattus norvegicus)
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Casp8 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q9JHX4
Gene Names
Casp8
Reference Genes
BioGPS Gene:64044 Casp8
ENSEMBL:ENSRNOG00000012331
ENSEMBL:ENSRNOG00000012331.7 Casp8
ENSEMBL:ENSRNOG00055023227
ENSEMBL:ENSRNOG00060017095
ENSEMBL:ENSRNOG00065029007
KEGG Gene (Rattus norvegicus):64044 Casp8
Monarch:64044 Casp8
NCBI Gene:64044 Casp8
UCSC:Q9JHX4 Casp8
Reference Transcript
RefSeq:XM_006245015.3 Casp8
RefSeq:NM_022277.1 Casp8
Other Identifiers
10923595
1369262_at
1380297_at
17859543
5755091
5762731
5836514
5842903
5939525
6222573
6374698
64044
6410446
6502559
6536256
6550784
A_44_P298210
GE1112482
GE1182044
GO:0002376
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006915
GO:0008233
GO:0008234
GO:0012501
GO:0016787
GO:0023052
GO:0030154
GO:0030163
GO:0031264
GO:0031265
GO:0031625
GO:0032731
GO:0032991
GO:0034612
GO:0035877
GO:0036462
GO:0042802
GO:0042981
GO:0043123
GO:0043124
GO:0043226
GO:0045651
GO:0045862
GO:0048856
GO:0051603
GO:0051604
GO:0060546
GO:0071260
GO:0097110
GO:0097153
GO:0097190
GO:0097191
GO:0097194
GO:0097199
GO:0097342
GO:0140096
ILMN_1371431
PH_rn_0008354
Participates
as a component of
Caspase-8 dimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
Casp8 [cytosol]
Casp8 [mitochondrial outer membrane]
Casp8 [mitochondrial outer membrane]
Casp8 [cytosol]
Casp8 [cytosol]
Inferred From
CASP8(217-374) [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_071613.1
,
XP_006245077.1
Ensembl
ENSRNOP00000016613
,
ENSRNOT00000016613
,
ENSRNOG00000012331
PRO
Q9JHX4
RGD
620945
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8R2E7
1
Fadd [cytosol]
(R-RNO-54639)
0.499
2
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