Reactome | LOC120103160 [extracellular region]

LOC120103160 [extracellular region]

Stable Identifier

R-RNO-877349-5

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

extracellular region

Synonyms

IFNA2, A0A8I6AEQ7

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Interferon Signaling (Rattus norvegicus)
    - Interferon alpha/beta signaling (Rattus norvegicus)
      - Activation of JAK kinases (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Formation of p-STAT1 homodimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - IFN alpha/beta binds to IFNAR2 (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Phosphorylation of INFAR1 by TYK2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Phosphorylation of STAT2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Recruitment of IFNAR1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Recruitment of STAT2 to p-IFNAR1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Regulation of IFNA/IFNB signaling (Rattus norvegicus)
        
        Dephosphorylation of JAK1 by SHP1 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        Dephosphorylation of STAT1 by SHP2 (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        Dephosphorylation of TYK2 by PTP1B (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
      - Release of p-STAT2:p-STAT1 dimer (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2 [plasma membrane] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)
        
        IFNA/B:IFNAR2:p-JAK1:STAT2:p-IFNAR1:p-TYK2:p-STAT2:p-STAT1 [plasma membrane] (Rattus norvegicus)
        
        IFN alpha/beta (IFNA/B) [extracellular region] (Rattus norvegicus)
        
        IFNA [extracellular region] (Rattus norvegicus)
        
        Homologues of IFNA2 [extracellular region] (Rattus norvegicus)
        
        LOC120103160 [extracellular region] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6AEQ7

Gene Names

LOC120103160

Reference Genes

ENSEMBL:ENSRNOG00000063583

ENSEMBL:ENSRNOG00000063583.1 LOC120103160

Reference Transcript

RefSeq:XM_001055007.3 LOC120103160

Other Identifiers

10869877

10869879

10869882

120103160

17799769

5694260

5697464

5742558

5751046

5919664

5997567

6234619

6343230

6507757

6551285

A_44_P375453

A_64_P004247

GO:0005126

GO:0005576

GO:0006952

ILMN_1358990

Participates

as a member of

Homologues of IFNA2 [extracellular region] (Rattus norvegicus)

Other forms of this molecule

LOC120103160 [extracellular region]

Inferred From

IFNA2 [extracellular region] (Homo sapiens)

Cross References

RefSeq

XP_001055007.1

Ensembl

ENSRNOP00000091570, ENSRNOG00000063583, ENSRNOT00000102021

RGD

41162071

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