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APP(672-713) [extracellular region]
Stable Identifier
R-RNO-879340
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
extracellular region
Synonyms
P08592
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Rattus norvegicus)
ECM proteoglycans (Rattus norvegicus)
AGRN binds Beta amyloid fibril via GAG chains (Rattus norvegicus)
AGRN:Beta amyloid fibril [extracellular region] (Rattus norvegicus)
Beta amyloid fibril [extracellular region] (Rattus norvegicus)
APP(672-713), APP(672-711) [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Beta amyloid fibril [extracellular region] (Rattus norvegicus)
APP(672-713), APP(672-711) [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Cytokine Signaling in Immune system (Rattus norvegicus)
Signaling by Interleukins (Rattus norvegicus)
Interleukin-1 family signaling (Rattus norvegicus)
Interleukin-1 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
Advanced glycosylation endproduct receptor signaling (Rattus norvegicus)
Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
DDX58/IFIH1-mediated induction of interferon-alpha/beta (Rattus norvegicus)
TRAF6 mediated NF-kB activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll-like Receptor Cascades (Rattus norvegicus)
Toll Like Receptor 10 (TLR10) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 2 (TLR2) Cascade (Rattus norvegicus)
Toll Like Receptor TLR1:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor TLR6:TLR2 Cascade (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 3 (TLR3) Cascade (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 4 (TLR4) Cascade (Rattus norvegicus)
MyD88-independent TLR4 cascade (Rattus norvegicus)
TRIF (TICAM1)-mediated TLR4 signaling (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 5 (TLR5) Cascade (Rattus norvegicus)
MyD88 cascade initiated on plasma membrane (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Toll Like Receptor 9 (TLR9) Cascade (Rattus norvegicus)
MyD88 dependent cascade initiated on endosome (Rattus norvegicus)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Rattus norvegicus)
TAK1-dependent IKK and NF-kappa-B activation (Rattus norvegicus)
NF-kappa-B complex is transported from cytosol to nucleus (Rattus norvegicus)
AGER ligands:AGER [plasma membrane] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G alpha (i) signalling events (Rattus norvegicus)
Liganded Gi-activating GPCR acts as a GEF for Gi (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
FPR2:FPR2 ligands [plasma membrane] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Rattus norvegicus)
FPR2:FPR2 ligands [plasma membrane] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
G alpha (q) signalling events (Rattus norvegicus)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
FPR2:FPR2 ligands [plasma membrane] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Rattus norvegicus)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Rattus norvegicus)
FPR2:FPR2 ligands [plasma membrane] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
GPCR ligand binding (Rattus norvegicus)
Class A/1 (Rhodopsin-like receptors) (Rattus norvegicus)
Peptide ligand-binding receptors (Rattus norvegicus)
Formyl peptide receptors bind formyl peptides and many other ligands (Rattus norvegicus)
FPR2 binds FPR2 ligands (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
FPR2:FPR2 ligands [plasma membrane] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
APP(672-713) [extracellular region] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P08592
Reference Genes
BioGPS Gene:54226
ENSEMBL:ENSRNOG00000006997
ENSEMBL:ENSRNOG00055002269
ENSEMBL:ENSRNOG00060016739
ENSEMBL:ENSRNOG00065006297
KEGG:rno:54226
Monarch:54226
NCBI Gene:54226
UCSC:P08592
Reference Transcript
RefSeq:NM_019288.2
Participates
as a member of
APP(672-713), APP(672-711) [extracellular region] (Rattus norvegicus)
AGER ligands [extracellular region] (Rattus norvegicus)
FPR2 ligands [extracellular region] (Rattus norvegicus)
Other forms of this molecule
APP(18-770) [trans-Golgi network membrane]
APP-C99 [cytosol]
APP (535-695) [cytosol]
APP [mitochondrial inner membrane]
APP(18-770) [extracellular region]
APP(18-770) [platelet alpha granule lumen]
APP(18-770) [endosome lumen]
phospho-p-APP [endoplasmic reticulum lumen]
APP [endoplasmic reticulum lumen]
APP(672-711) [extracellular region]
Inferred From
APP(672-713) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_062161.1
PRO
P08592
GlyGen
P08592
RGD
2139
PDB
1NMJ
,
1OQN
,
1M7E
,
2LI9
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