Passive Transport of Anions out of Vesicles by Aquaporin-6 (rat)

Stable Identifier
R-RNO-879863
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Passive Transport of Anions out of Vesicles by Aquaporin-6 (rat)
Rat Aquaporin-6 (AQP6) passively transports anions with the specificity: nitrate > iodide > bromide > chloride > fluoride. AQP6 weakly transports water. AQP6 is gated by low pH.
Literature References
PubMed ID Title Journal Year
12177001 Characterization of aquaporin-6 as a nitrate channel in mammalian cells. Requirement of pore-lining residue threonine 63

Kozono, D, Yasui, M, Ikeda, M, Agre, P, Guggino, WB, Beitz, E

J Biol Chem 2002
12034750 Ion permeation of AQP6 water channel protein. Single channel recordings after Hg2+ activation

Kozono, D, Yasui, M, Hazama, A, Agre, P, Guggino, WB

J Biol Chem 2002
15892693 Determinants of AQP6 trafficking to intracellular sites versus the plasma membrane in transfected mammalian cells

Yasui, M, Ikeda, M, Liu, K, Agre, P, Guggino, WB, Beitz, E

Biol Cell 2006
10647010 Rapid gating and anion permeability of an intracellular aquaporin

Yasui, M, Hazama, A, Kwon, TH, Nielsen, S, Agre, P, Guggino, WB

Nature 1999
15671159 Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution

Kato, Y, Kozono, D, Yasui, M, Hazama, A, Liu, K, Agre, P

Proc Natl Acad Sci U S A 2005
Participants
Event Information
Catalyst Activity

anion channel activity of Aquaporin-6 [transport vesicle membrane]

Orthologous Events
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