Reactome | Tra2b [nucleoplasm]

Tra2b [nucleoplasm]

Stable Identifier

R-RNO-8850859

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

TRA2B, P62997

Locations in the PathwayBrowser

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Metabolism of RNA (Rattus norvegicus)

- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - Formation of pre-mRNPs (Rattus norvegicus)
    - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
      - Tra2b [nucleoplasm] (Rattus norvegicus)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
      - Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
  - mRNA 3'-end processing (Rattus norvegicus)
    - mRNA Polyadenylation (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Core CPA complex binds capped pre-mRNA (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Rattus norvegicus)
        
        Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - PP1 dephosphorylates RNA Pol II (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - RBBP6 activates CPSF complex (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Recruitment of other CPA components to pre-mRNA-bound CPA core (Rattus norvegicus)
        
        CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
  - mRNA Splicing (Rattus norvegicus)
    - mRNA Splicing - Major Pathway (Rattus norvegicus)
      - Formation of the Spliceosomal B* complex (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal Bact complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C complex containing intron lariat (Rattus norvegicus)
        
        Spliceosomal B* complex [nucleoplasm] (Rattus norvegicus)
        
        capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal C* complex (Rattus norvegicus)
        
        Spliceosomal C complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Formation of the Spliceosomal P complex and exon ligation (Rattus norvegicus)
        
        Spliceosomal C* complex [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Rattus norvegicus)
        
        Spliceosomal P complex [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Rattus norvegicus)
        
        Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)
        
        Tra2b [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P62997

Gene Names

Tra2b

Reference Genes

BioGPS Gene:117259 Tra2b

ENSEMBL:ENSRNOG00000001783

KEGG:rno:117259 Tra2b

Monarch:117259 Tra2b

NCBI Gene:117259 Tra2b

UCSC:P62997 Tra2b

Reference Transcript

RefSeq:NM_057119.1 Tra2b

Other Identifiers

10752050

117259

1370188_at

1370189_at

17666704

5671634

5863126

5867175

5981704

6049896

6084016

6158714

6175311

6188592

6226670

6280135

6298864

6349787

6408140

6413368

6461298

6498333

6631906

6644691

6704568

A_43_P13035

D49708_at

GE21605

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005637

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0016071

GO:0019904

GO:0021796

GO:0032991

GO:0036002

GO:0042802

GO:0043484

GO:0048026

GO:0048856

GO:0071333

GO:1990403

ILMN_1372000

PH_rn_0006556

rc_AA851749_s_at

rc_AI231164_s_at

Participates

as a member of

Alternative Splicing Factors [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

Tra2b [cytosol]

Inferred From

TRA2B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_476460.1

ENSEMBL

ENSRNOT00000102904, ENSRNOP00000095605, ENSRNOG00000001783

PRO

P62997

RGD

619886

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