Tspan7 binds Pick1

Stable Identifier
Reaction [binding]
Rattus norvegicus
SVG |   | PPTX  | SBGN
Tspan7 binds Pick1

Tetraspanin 7 (TSPAN7) a member of the tetraspanin superfamily associates dynamically with numerous partner proteins in tetraspanin-enriched microdomains (TEMs) of the plasma membrane (Boucheix and Rubinstein, 2001). TSPAN7 promotes filopodia and dendritic spine formation in cultured hippocampal neurons, and is required for spine stability and normal synaptic transmission. Via its C-terminus, TSPAN7 interacts with the PDZ domain of protein interacting with C kinase 1 (PICK1), to regulate PICK1 and GluR2/3 association and AMPA receptor trafficking (Bassani et al. 2012). PICK1 is involved in the internalization and recycling of AMPA receptors (AMPARs) (Perez et al. 2001). In hippocampal neurons, TSPAN7 may regulate AMPA receptor trafficking by limiting PICK1 accessibility to AMPA receptors and suggest an additional mechanism for the functional maturation of glutamatergic synapses, whose impairment is implicated in intellectual disability (Bassani et al. 2012).

Literature References
PubMed ID Title Journal Year
22445342 The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking

Bassani, S, Cingolani, LA, Valnegri, P, Folci, A, Zapata, J, Gianfelice, A, Sala, C, Goda, Y, Passafaro, M

Neuron 2012
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