Reactome | Klhl22 [cytosol]

Klhl22 [cytosol]

Stable Identifier

R-RNO-8863210

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

KLHL22, D3ZZC3

Locations in the PathwayBrowser

Expand all

Immune System (Rattus norvegicus)

- Adaptive Immune System (Rattus norvegicus)
  - Class I MHC mediated antigen processing & presentation (Rattus norvegicus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Rattus norvegicus)
      - Interaction of E3 with substrate and E2-Ub complex (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - Polyubiquitination of substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - Release of E3 from polyubiquitinated substrate (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - Transfer of Ub from E2 to substrate and release of E2 (Rattus norvegicus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
        
        E3:Ub:substrate [cytosol] (Rattus norvegicus)
        
        E3 ligases in proteasomal degradation [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Rattus norvegicus)
        
        CRL E3 ubiquitin ligases [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        RBX1:CUL3:BTB [cytosol] (Rattus norvegicus)
        
        BTB proteins [cytosol] (Rattus norvegicus)
        
        Klhl22 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D3ZZC3

Gene Names

Klhl22

Reference Genes

BioGPS Gene:303792 Klhl22

ENSEMBL:ENSRNOG00000001878

ENSEMBL:ENSRNOG00055003606

ENSEMBL:ENSRNOG00060012995

ENSEMBL:ENSRNOG00065008036

KEGG Gene (Rattus norvegicus):303792 Klhl22

Monarch:303792 Klhl22

NCBI Gene:303792 Klhl22

Reference Transcript

Participates

as a member of

BTB proteins [cytosol] (Rattus norvegicus)

Inferred From

KLHL22 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001100549.1, XP_006248763.1

PRO

D3ZZC3

RGD

1306288

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