Reactome | apoTF [clathrin-coated endocytic vesicle membrane]

apoTF [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-RNO-8869140

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

P12346

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
    - RAB5 and GAPVD1 bind AP-2 (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2:cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)
        
        apoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P12346

Reference Genes

BioGPS Gene:24825

ENSEMBL:ENSRNOG00000030625

ENSEMBL:ENSRNOG00055011836

ENSEMBL:ENSRNOG00060008627

ENSEMBL:ENSRNOG00065007831

KEGG:rno:24825

Monarch:24825

NCBI Gene:24825

UCSC:P12346

Reference Transcript

RefSeq:NM_001013110.1

Other Identifiers

10919626

10919637

1370228_at

1382166_at

1390178_at

17855076

17855085

24825

5635913

5639192

5651005

5655039

5682752

5731851

5735258

5749951

5819646

5820097

5830828

5840694

5846209

5880854

5921567

5934756

5953670

5978830

5982601

6091708

6098020

6106495

6109510

6151702

6157340

6303783

6332729

6354451

6410619

6452833

6487140

6508750

6531781

6565377

6668642

6698151

6699792

6725203

AA800339_at

A_44_P128147

A_44_P487841

A_44_P572450

A_64_P044757

D38380_at

D38380_g_at

GE1204686

GE1227220

GO:0005576

GO:0005615

GO:0006826

GO:0006879

GO:0008199

ILMN_1376249

PH_rn_0002211

PH_rn_0015719

U31866_g_at

Participates

as a component of

holoTF [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Other forms of this molecule

TF [secretory granule lumen]

phospho-p-TF [endoplasmic reticulum lumen]

TF [endoplasmic reticulum lumen]

apoTF [endosome membrane]

apoTF [extracellular region]

Inferred From

apoTF [clathrin-coated endocytic vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001013128.1

ENSEMBL

ENSRNOT00000045628, ENSRNOG00000030625, ENSRNOP00000045637

PRO

P12346

GlyGen

P12346

RGD

3845

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