PKC phosphorylates Nrf2

Stable Identifier
R-RNO-8932373
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PKC phosphorylates Nrf2
In response to oxidative stress, protein kinase C (PKC) phosphorylates NFE2L2 (NRF2) at residue serine 40 (Ser-40). It has been demonstrated that NRF2 phosphorylation at Ser-40 facilitates its nuclear translocation (Huang et al. 2002).
Literature References
PubMed ID Title Journal Year
12198130 Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

Nguyen, T, Pickett, CB, Huang, HC

J. Biol. Chem. 2002
Participants
Input
Output
Catalyst Activity

diacylglycerol-dependent serine/threonine kinase activity of Prkcd [cytosol]

Physical Entity
Prkcd [cytosol] (Rattus norvegicus)
Activity
diacylglycerol-dependent serine/threonine kinase activity (GO:0004697)
This event is regulated
Positively by
Regulator
ROS [cytosol]
Orthologous Events
PKC phosphorylates NFE2L2 (Homo sapiens)
Authored
Garapati, P V  (2016-07-22)
Reviewed
Somers, J  (2021-01-23)
Created
Garapati, P V  (2016-07-22)
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