Reactome | PTPN11 [nucleoplasm]

PTPN11 [nucleoplasm]

Stable Identifier

R-RNO-8937745

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

P41499

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P41499 Ptpn11

Gene Names

Ptpn11

Chain

initiator methionine:, chain:2-593

Reference Genes

BioGPS Gene:25622 Ptpn11

Monarch:25622 Ptpn11

NCBI Gene:25622 Ptpn11

UCSC:P41499 Ptpn11

Reference Transcript

Participates

as an output of

PTPN11 dephosphorylates RUNX1 (Rattus norvegicus)

as an input of

PTPN11 binds p-7Y-RUNX1 (Rattus norvegicus)

as a component of

p-7Y-RUNX1:PTPN11 [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

p-Y-Shp2 [cytosol]

Ptpn11 [cytosol]

PTPN11 [cytosol]

phospho-p-Y542,Y580-PTPN11 [cytosol]

Inferred From

PTPN11 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_037220.2, NP_001171064.1

IntEnz

3.1.3.48

PRO

P41499

RGD

3447

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09619 PDGFRB	3	p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) PDGFRB [plasma membrane] (R-HSA-186767) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.59	4
UniProt:P97710 Sirpa	6	pSirpa_Rat [plasma membrane] (R-RNO-548918) Sirpa_Rat [plasma membrane] (R-RNO-548921) phospho-Sirpa [plasma membrane] (R-RNO-391102) Sirpa [ficolin-1-rich granule membrane] (R-RNO-6803321) Sirpa [tertiary granule membrane] (R-RNO-6803288) Sirpa [plasma membrane] (R-RNO-3209922)	0.544	3

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