p-Y-Yap1 translocates to the nucleus

Stable Identifier
R-RNO-8937920
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
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p-Y-Yap1 translocates to the nucleus
In rat osteosarcoma cells, Yap1, phosphorylated on an unknown tyrosine residue by activated Src and/or Yes1, translocates to the nucleus. Tyrosine phosphorylation does not change the ratio of nuclear and cytosolic Yap1 (Zaidi et al. 2004).
Literature References
PubMed ID Title Journal Year
14765127 Tyrosine phosphorylation controls Runx2-mediated subnuclear targeting of YAP to repress transcription

van Wijnen, AJ, Ito, Y, Medina, R, Lian, JB, Stein, JL, Stein, GS, Sullivan, AJ, Zaidi, SK

EMBO J. 2004
Participants
Input
Output
Orthologous Events
p-Y-YAP1 translocates to the nucleus (Homo sapiens)
Authored
Orlic-Milacic, M  (2016-09-07)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2016-09-07)
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