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Cul3 [cytosol]
Stable Identifier
R-RNO-8952516
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
G76-NEDD8-K712-CUL3, B5DF89
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
CUL3:RBX1 ubiquitinates KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:CUL3:RBX1 ubiquitinates p-S349 SQSTM1 oligomer (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
MAP1LC3B binds KEAP1 and SQSTM1 (Rattus norvegicus)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers bind to KEAP1:CUL3:RBX1:NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
RBX1:CUL3 dissociates from forming autophagosome (Rattus norvegicus)
MAP1LC3B:SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
SESN1,SESN2:ub-K420 p-S349 SQSTM1 oligomer:ub-KEAP1:CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
SESN1,SESN1 bind SQSTM1 and KEAP1 (Rattus norvegicus)
SESN1,2:ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-K420 p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer binds KEAP1:CUL3:RBX1 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
p-S349 SQSTM1 oligomer:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Neddylation (Rattus norvegicus)
AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 complex ubiquitinates NFE2L2 (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
NFE2L2 inducers:KEAP1:CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1:NFE2L2 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Cul3 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:B5DF89
Gene Names
Cul3
Reference Genes
ENSEMBL:ENSRNOG00000015633
ENSEMBL:ENSRNOG00055006821
ENSEMBL:ENSRNOG00060007351
ENSEMBL:ENSRNOG00065018395
UCSC:B5DF89 Cul3
Reference Transcript
RefSeq:XM_017596375.1 Cul3
RefSeq:XM_017596374.1 Cul3
RefSeq:XM_008767226.2 Cul3
Participates
as a component of
NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
NEDD8-CUL3:RBX1:BTB [cytosol] (Rattus norvegicus)
KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
ub-KEAP1:NEDD8-CUL3:RBX1 [cytosol] (Rattus norvegicus)
Other forms of this molecule
Cul3 [nucleoplasm]
Cul3 [cytosol]
Inferred From
G76-NEDD8-K712-CUL3 [cytosol]
(Homo sapiens)
Modified Residues
Name
neddylated lysine (monoNEDD8 [cytosol]) at 712 (in Homo sapiens)
Coordinate
712
Modification
monoNEDD8 [cytosol]
PsiMod Name
neddylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a nedd8 protein.
Cross References
RefSeq
XP_017451863.1
,
XP_008765448.1
,
XP_017451864.1
PRO
B5DF89
RGD
1308190
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