Reactome | Commd6 [cytosol]

Commd6 [cytosol]

Stable Identifier

R-RNO-8955098

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

COMMD6, D4A8E7

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Rattus norvegicus)

- Post-translational protein modification (Rattus norvegicus)
  - Neddylation (Rattus norvegicus)
    - 26S proteasome degrades HIFalpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Rattus norvegicus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Rattus norvegicus)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL2 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL2 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Rattus norvegicus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
    - VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)
      - ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Rattus norvegicus)
        
        COMMDs:CCDC22 [cytosol] (Rattus norvegicus)
        
        COMMDs [cytosol] (Rattus norvegicus)
        
        Commd6 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:D4A8E7

Gene Names

Commd6

Reference Genes

BioGPS Gene:498559 Commd6

ENSEMBL:ENSRNOG00000038012

ENSEMBL:ENSRNOG00000038012.3 Commd6

KEGG Gene (Rattus norvegicus):498559 Commd6

Monarch:498559 Commd6

NCBI Gene:498559 Commd6

UCSC:D4A8E7 Commd6

Reference Transcript

RefSeq:NM_001109105.1 Commd6

Other Identifiers

10785620

1389144_at

17704977

498559

5888057

5917119

5971694

6006540

6423745

6477581

6643307

6704712

A_64_P126335

GE12390

GO:0051059

ILMN_1361470

PH_rn_0009355

rc_AA818759_at

rc_AA850154_at

Participates

as a candidate of

COMMDs [cytosol] (Rattus norvegicus)

Other forms of this molecule

Commd6 [nucleoplasm]

Inferred From

COMMD6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001102575.1

Ensembl

ENSRNOP00000054640, ENSRNOT00000057830, ENSRNOG00000038012

RGD

1560745

Cite Us!