Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu

Stable Identifier
R-RNO-9012709
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
mitochondrial matrix
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Got2:PLXP dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu
Rat mitochondrial (Got2) (Cechetto et al. 2002) is a dimeric protein requiring pyridoxal phosphate for activity. Got2 mediates the reversible transamination between L-cysteine (L-Cys) and 2-oxoglutarate (2OG, aka alpha-ketoglutarate) to form 3-methylpyruvate (3MPYR) and glutamate (Glu) (Ubuka et al. 1978).
Literature References
PubMed ID Title Journal Year
11962739 Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues

Cechetto, JD, Berk, PD, Gupta, RS, Sadacharan, SK

Histol. Histopathol. 2002
754189 Purification and characterization of mitochondrial cysteine aminotransferase from rat liver

Ubuka, T, Umemura, S, Watanabe, K, Yuasa, S, Kinuta, M

Physiol. Chem. Phys. 1978
Participants
Input
Output
Catalyst Activity

L-cysteine transaminase activity of Got2 dimer [mitochondrial matrix]

Physical Entity
Got2 dimer [mitochondrial matrix] (Rattus norvegicus)
Activity
L-cysteine transaminase activity (GO:0047801)
Orthologous Events
GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu (Homo sapiens)
Authored
Jassal, B  (2017-07-18)
Reviewed
Kimura, H  (2018-01-11)
Created
Jassal, B  (2017-07-18)
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