Reactome | phospho-Shc1 [cytosol]

phospho-Shc1 [cytosol]

Stable Identifier

R-RNO-912321

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-Y349,Y350,Y427-SHC1, Q5M824

Locations in the PathwayBrowser

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Developmental Biology (Rattus norvegicus)

- Nervous system development (Rattus norvegicus)
  - Axon guidance (Rattus norvegicus)
    - RET signaling (Rattus norvegicus)
      - 2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - GAB in p-5Y-RET:GDNF:GFRA complexes is phosphorylated (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - SHC1 in the RET complex is phosphorylated (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - p-5Y-GAB in RET-GRB2-GAB complexes binds PTPN11 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:PTPN11 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - p-5Y-GAB in the RET-GRB2-GAB complexes binds p85-PI3K (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:p-5Y-GAB1,p-5Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - p-5Y-RET complexes bind GRB2 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        p-5Y-RET:GDNF:GFRA complexes with and without p-SHC1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
      - p-5Y-RET-GRB2-containing complexes bind GAB1,GAB2 (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1:GAB1,GAB2 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes with, without p-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1 [plasma membrane] (Rattus norvegicus)
        
        2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)

Immune System (Rattus norvegicus)

- Cytokine Signaling in Immune system (Rattus norvegicus)
  - Signaling by Interleukins (Rattus norvegicus)
    - Interleukin-2 family signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
    - Interleukin-3, Interleukin-5 and GM-CSF signaling (Rattus norvegicus)
      - Interleukin receptor SHC signaling (Rattus norvegicus)
        
        Gab2 binds the p85 subunit of Class 1A PI3 kinases (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC recruits GRB2:SOS1 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits GRB2:GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Phosphorylated SHC1 recruits SHIP (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        SHC1 mediates cytokine-induced phosphorylation of GAB2 (Rattus norvegicus)
        
        Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)- Bc:p(427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1:GRB2:p(Y)-GAB2 [plasma membrane] (Rattus norvegicus)
        
        IL3:IL3R active complex, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        The SHC1:SHIP1 complex is stabilized by GRB2 (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Rattus norvegicus)
        
        Interleukin receptor complexes with activated SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)
        
        IL3:IL3R active complex, inactive JAK2, phosphorylated Bc:p(Y427,349,350)-SHC1 [plasma membrane] (Rattus norvegicus)
        
        phospho-Shc1 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q5M824 Shc1

Gene Names

Shc1

Chain

chain:1-469

Reference Genes

BioGPS Gene:85385 Shc1

KEGG Gene (Rattus norvegicus):85385 Shc1

Monarch:85385 Shc1

NCBI Gene:85385 Shc1

UCSC:Q5M824 Shc1

Reference Transcript

RefSeq:NM_053517.2 Shc1

Participates

as a candidate of

p-3Y SHC1-1,SHC1-2,SHC1-3 [cytosol] (Rattus norvegicus)

as an input of

as an output of

p-3Y-SHC1 dissociates from IGF1R (Rattus norvegicus)

as a component of

Other forms of this molecule

Shc1 [plasma membrane]

p-Y314-Shc1 [cytosol]

Shc1 [cytosol]

phospho-Shc1 [cytosol]

Shc1 [cytosol]

phospho-Shc1 [cytosol]

phospho-Shc1 [plasma membrane]

Shc1 [cytosol]

phospho-Shc1 [cytosol]

Inferred From

p-3Y-SHC1 [cytosol] (Homo sapiens)

p-3Y-SHC1-1,p-3Y-SHC1-2 [cytosol] (Homo sapiens)

p-Y349,Y350,Y427-SHC1-1 [cytosol] (Homo sapiens)

p-Y349,Y350,Y427-SHC1 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 427 (in Homo sapiens)

Coordinate

427

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 349 (in Homo sapiens)

Coordinate

349

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 350 (in Homo sapiens)

Coordinate

350

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_445969.2

PRO

Q5M824

RGD

620446

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:B5DFH1 B5DFH1			0.463	2

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