Reactome | Tfrc [plasma membrane]

Tfrc [plasma membrane]

Stable Identifier

R-RNO-917983

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

TFRC(1-760), Q99376

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - SNX9 recruits components of the actin polymerizing machinery (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q99376

Gene Names

Tfrc

Reference Genes

BioGPS Gene:64678 Tfrc

ENSEMBL:ENSRNOG00000001766

ENSEMBL:ENSRNOG00000001766 Tfrc

KEGG Gene (Rattus norvegicus):64678 Tfrc

Monarch:64678 Tfrc

NCBI Gene:64678 Tfrc

UCSC:Q99376 Tfrc

Reference Transcript

Participates

as a candidate of

as a component of

TFRC dimer [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Tfrc [clathrin-coated endocytic vesicle membrane]

Tfrc [Golgi membrane]

Tfrc [cytoplasmic vesicle membrane]

Tfrc [endosome membrane]

Inferred From

TFRC(1-760) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_073203.1, XP_006248525.1, XP_006248524.1

GlyGen

Q99376

RGD

70488

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.499	3

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