Reactome | Tfrc [plasma membrane]

Tfrc [plasma membrane]

Stable Identifier

R-RNO-917983

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

TFRC(1-760), Q99376

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - AP-2 directly binds some endocytic cargo (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2:cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 cargo [plasma membrane] (Rattus norvegicus)
        
        AP-2 YXXPhi cargo [plasma membrane] (Rattus norvegicus)
        
        holoTF:TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        TFRC dimer [plasma membrane] (Rattus norvegicus)
        
        Tfrc [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q99376

Gene Names

Tfrc

Reference Genes

BioGPS Gene:64678 Tfrc

ENSEMBL:ENSRNOG00000001766

KEGG Gene (Rattus norvegicus):64678 Tfrc

Monarch:64678 Tfrc

NCBI Gene:64678 Tfrc

UCSC:Q99376 Tfrc

Reference Transcript

Other Identifiers

10754785

1371113_a_at

1388750_at

17669755

5649068

5709075

5750427

5787004

5826456

6067776

6073866

6143381

6197333

6234578

6245662

6262138

6285408

6345050

6371980

6432117

64678

6487838

6592763

6681836

6687990

6709269

A_43_P15662

A_44_P214811

A_44_P313767

GE16781

GO:0001666

GO:0001934

GO:0002376

GO:0003723

GO:0003725

GO:0004998

GO:0005515

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005768

GO:0005769

GO:0005886

GO:0005887

GO:0005905

GO:0006310

GO:0006351

GO:0006355

GO:0006826

GO:0006879

GO:0006897

GO:0006898

GO:0006953

GO:0006954

GO:0007005

GO:0007155

GO:0007568

GO:0007584

GO:0009897

GO:0009986

GO:0010008

GO:0010033

GO:0010035

GO:0010039

GO:0010042

GO:0010628

GO:0010637

GO:0012501

GO:0016020

GO:0016021

GO:0016192

GO:0016323

GO:0019901

GO:0023052

GO:0030154

GO:0030316

GO:0030544

GO:0030890

GO:0031334

GO:0031410

GO:0031623

GO:0032526

GO:0032991

GO:0033138

GO:0033572

GO:0035556

GO:0036211

GO:0038024

GO:0042102

GO:0042470

GO:0042802

GO:0042803

GO:0043066

GO:0043123

GO:0043226

GO:0043231

GO:0044877

GO:0045780

GO:0045830

GO:0046688

GO:0048471

GO:0048856

GO:0051087

GO:0051092

GO:0055037

GO:0055038

GO:0055065

GO:0065003

GO:0070062

GO:0071466

GO:0110165

GO:1900182

GO:1990712

GO:1990830

ILMN_1360908

M58040_at

PH_rn_0012051

PH_rn_0021802

rc_AI237645_at

Participates

as a candidate of

as a component of

TFRC dimer [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

Tfrc [clathrin-coated endocytic vesicle membrane]

Tfrc [Golgi membrane]

Tfrc [cytoplasmic vesicle membrane]

Tfrc [endosome membrane]

Inferred From

TFRC(1-760) [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_006248525.1, NP_073203.1, XP_006248524.1

Ensembl

ENSRNOG00000001766, ENSRNOP00000002407, ENSRNOT00000002407

RGD

70488

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.499	3

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