Reactome | phospho-Autophosphorylated FLT3 [plasma membrane]

phospho-Autophosphorylated FLT3 [plasma membrane]

Stable Identifier

R-RNO-9604780

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

A0A0G2JW59

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- Intracellular signaling by second messengers (Rattus norvegicus)
  - PIP3 activates AKT signaling (Rattus norvegicus)
    - Negative regulation of the PI3K/AKT network (Rattus norvegicus)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Rattus norvegicus)
        
        PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
        
        Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3: GRB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3 [plasma membrane] (Rattus norvegicus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Rattus norvegicus)
    - PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
      - Activator:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y GAB2:PI3K [plasma membrane] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3: GRB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3 [plasma membrane] (Rattus norvegicus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Rattus norvegicus)
- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Active FLT3:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3: GRB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3 [plasma membrane] (Rattus norvegicus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Rattus norvegicus)
- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by Insulin receptor (Rattus norvegicus)
    - Insulin receptor signalling cascade (Rattus norvegicus)
      - IRS-mediated signalling (Rattus norvegicus)
        
        PI3K Cascade (Rattus norvegicus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
        
        PI3K-containing complexes [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3: GRB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3 [plasma membrane] (Rattus norvegicus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Rattus norvegicus)
  - Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Rattus norvegicus)
    - IGF1R signaling cascade (Rattus norvegicus)
      - IRS-related events triggered by IGF1R (Rattus norvegicus)
        
        IRS-mediated signalling (Rattus norvegicus)
        
        PI3K Cascade (Rattus norvegicus)
        
        PI3K-containing complexes phosphorylate PIP2 to PIP3 (Rattus norvegicus)
        
        PI3K-containing complexes [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2:PIK3R1 [cytosol] (Rattus norvegicus)
        
        Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3: GRB2 [plasma membrane] (Rattus norvegicus)
        
        Active FLT3 [plasma membrane] (Rattus norvegicus)
        
        phospho-Autophosphorylated FLT3 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A0G2JW59

Reference Genes

ENSEMBL:ENSRNOG00000054764

KEGG:rno:140635

UCSC:A0A0G2JW59

Other Identifiers

10756455

1377882_at

140635

17671603

5620226

5624329

5629114

5643658

5663651

5668527

5730279

5810363

5888546

5939010

5951483

5999012

6032364

6063505

6131376

6145077

6153754

6161848

6210911

6339935

6341526

6348326

6368790

6391534

6395642

6402344

6408225

6469737

6549143

6600619

6713772

6716615

A_43_P15840

A_44_P252756

A_64_P026374

A_64_P026377

GE1147163

GE19330

GO:0000166

GO:0001776

GO:0002318

GO:0002320

GO:0002328

GO:0002376

GO:0002572

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0004888

GO:0004896

GO:0005524

GO:0005783

GO:0005788

GO:0005886

GO:0006468

GO:0007166

GO:0007169

GO:0008283

GO:0008284

GO:0008285

GO:0009791

GO:0009897

GO:0009986

GO:0010604

GO:0016020

GO:0016301

GO:0016477

GO:0016740

GO:0019221

GO:0019838

GO:0019882

GO:0030097

GO:0030098

GO:0030154

GO:0030183

GO:0031625

GO:0032715

GO:0032720

GO:0032727

GO:0032729

GO:0032735

GO:0032991

GO:0035259

GO:0035726

GO:0036145

GO:0040018

GO:0043235

GO:0043548

GO:0044877

GO:0045578

GO:0046651

GO:0046872

GO:0048513

GO:0048535

GO:0048536

GO:0048731

GO:0048856

GO:0048870

GO:0048873

GO:0071345

GO:0071385

GO:0097028

GO:0097421

GO:0098586

GO:0140096

ILMN_1358338

PH_rn_0011600

rc_AA996414_at

Participates

as a component of

Active FLT3 [plasma membrane] (Rattus norvegicus)

Other forms of this molecule

FLT3 [plasma membrane]

Inferred From

Autophosphorylated FLT3 [plasma membrane] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 589 (in Homo sapiens)

Coordinate

589

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 591 (in Homo sapiens)

Coordinate

591

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 599 (in Homo sapiens)

Coordinate

599

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 768 (in Homo sapiens)

Coordinate

768

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 955 (in Homo sapiens)

Coordinate

955

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 969 (in Homo sapiens)

Coordinate

969

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

ENSEMBL

ENSRNOG00000054764, ENSRNOP00000069753, ENSRNOT00000088957

RGD

61308

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