Reactome | GluN3A (Grin3a), GluN3B (Grin3b) NMDA receptors traffic to the plasma membrane

GluN3A (Grin3a), GluN3B (Grin3b) NMDA receptors traffic to the plasma membrane

Stable Identifier

R-RNO-9610782

Type

Reaction [omitted]

Species

Rattus norvegicus

Compartment

endoplasmic reticulum membrane, plasma membrane

ReviewStatus

5/5

General

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GluN3A (Grin3a), GluN3B (Grin3b) NMDA receptors traffic to the plasma membrane

In rat neurons, NMDA receptors that contain GluN3A (Grin3a) or GluN3B (Grin3b) subunits, traffic to the plasma membrane to the perisynaptic regions, located at the periphery of the postsynaptic density (PSD). GluN3a and GluN3b do not have PDZ-binding domains and thus do not interact directly with PSD-95 family members. A small fraction of GluN3-containing NMDA receptors that localize to the central region of the PSD may be tri-heteromers with GluN2 subunits (Perez-Otano et al. 2006, Wee et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
16617342	Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1 Pérez-Otaño, I, Luján, R, Tavalin, SJ, Plomann, M, Modregger, J, Liu, XB, Jones, EG, Heinemann, SF, Lo, DC, Ehlers, MD	Nat. Neurosci.	2006
26700428	Ontogenic Profile and Synaptic Distribution of GluN3 Proteins in the Rat Brain and Hippocampal Neurons Wee, KS, Tan, FC, Cheong, YP, Khanna, S, Low, CM	Neurochem. Res.	2016