Reactome | Camk2a [cytosol]

Camk2a [cytosol]

Stable Identifier

R-RNO-9611390

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

Calcium/calmodulin-dependent protein kinase type II subunit alpha, KCC2A_RAT

Locations in the PathwayBrowser

Expand all

Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        CaMKII dodecamer [cytosol] (Rattus norvegicus)
        
        CAMK2A,CAMK2B,(CAMK2D,CAMK2G) [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)
- Signaling by WNT (Rattus norvegicus)
  - Beta-catenin independent WNT signaling (Rattus norvegicus)
    - Ca2+ pathway (Rattus norvegicus)
      - Active calmodulin binds CAMK2 (Rattus norvegicus)
        
        CAMK2:CaM [cytosol] (Rattus norvegicus)
        
        CAMK2A [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)
        
        CAMK2A [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)
      - Autophosphorylation and activation of CAMK2 (Rattus norvegicus)
        
        CAMK2:CaM [cytosol] (Rattus norvegicus)
        
        CAMK2A [cytosol] (Rattus norvegicus)
        
        Camk2a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P11275 Camk2a

Gene Names

Camk2a

Chain

chain:1-478

Reference Genes

BioGPS Gene:25400 Camk2a

KEGG Gene (Rattus norvegicus):25400 Camk2a

Monarch:25400 Camk2a

NCBI Gene:25400 Camk2a

UCSC:P11275 Camk2a

Reference Transcript

RefSeq:NM_012920.1 Camk2a

Participates

as an output of

Ppm1f dephosphorylates p-T286-CaMKII-alpha (Rattus norvegicus)

as a component of

CAMK2A [cytosol] (Rattus norvegicus)

as a member of

Other forms of this molecule

phospho-p-T286-CAMK2A [plasma membrane]

phospho-p-T286-CAMK2A [nucleoplasm]

phospho-p-T286-CAMK2A [endocytic vesicle membrane]

phospho-p-T286,T305,T306-CAMK2A [cytosol]

p-T286-Camk2a [cytosol]

Inferred From

CAMK2A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_037052.1

PRO

P11275

RGD

2261

PDB

1CM4, 1CDM, 1CM1, 5U6Y

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08485	1	Chrm4 [plasma membrane] (R-RNO-390693)	0.645	10
UniProt:Q00959 Grin2a	3	p-Y-Grin2a [plasma membrane] (R-RNO-9628245) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) Grin2a [plasma membrane] (R-RNO-6794271)	0.589	2
UniProt:Q00960 Grin2b	7	phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-RNO-3928477) p-Y1472-Grin2b [plasma membrane] (R-RNO-9032617) p-Y-Grin2b [plasma membrane] (R-RNO-9628248) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609846) GRIN2B [endoplasmic reticulum membrane] (R-RNO-9609765) Grin2b [plasma membrane] (R-RNO-6794241) GRIN2B [plasma membrane] (R-RNO-419558)	0.589	2
UniProt:P19490 Gria1	7	GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811) GRIA1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) GRIA1 [endoplasmic reticulum membrane] (R-RNO-5689460) p-S849-Gria1 [plasma membrane] (R-RNO-9620442) Gria1 [plasma membrane] (R-RNO-9620440) GRIA1 [endocytic vesicle membrane] (R-RNO-3004479) GRIA1 [plasma membrane] (R-RNO-3004495)	0.567	4
UniProt:P54282	1	CACNA1A [plasma membrane] (R-RNO-210490)	0.524	3
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.488	2
UniProt:Q63347	5	PSMC2 [secretory granule lumen] (R-RNO-6800994) PSMC2 [extracellular region] (R-RNO-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-RNO-6800421) PSMC2 [nucleoplasm] (R-RNO-174332) PSMC2 [cytosol] (R-RNO-68771)	0.463	2