Src phosphorylates GluN2 (Grin2) subunits of NMDARs

Stable Identifier
R-RNO-9612145
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Src phosphorylates GluN2 (Grin2) subunits of NMDARs
In rat cortical neurons, non-receptor tyrosine kinase Src phosphorylates GluN2 (Grin2, Nr2) subunits of the GluN2-containing NMDA receptors (NMDARs). This increases NMDAR open time and activity (Yu et al. 1997) and plays a role in long-term potentiation. Treatment of rat cortical neurons with Erbb4 ligand Nrg1-beta1 negatively regulates phosphorylation of NMDARs by Src. Treatment of brain slices from Erbb4 knockout mice with Nrg1-beta1 does not affect Src-mediated increase in NMDAR activity (Pitcher et al. 2011).
Literature References
PubMed ID Title Journal Year
21441918 Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors

Kalia, LV, Pitcher, GM, Goodfellow, NM, Yee, KT, Ng, D, Lambe, EK, Salter, MW

Nat. Med. 2011
9005855 NMDA channel regulation by channel-associated protein tyrosine kinase Src

Keil, GJ, Askalan, R, Yu, XM, Salter, MW

Science 1997
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of MyrG-p-Y419-Src [plasma membrane]

Physical Entity
MyrG-p-Y419-Src [plasma membrane] (Rattus norvegicus)
Activity
protein tyrosine kinase activity (GO:0004713)
This event is regulated
Negatively by
Regulator
Nrg1-beta1 [extracellular region] (Rattus norvegicus)
Orthologous Events
SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-06-26)
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