Reactome | Dlg4 [plasma membrane]

Dlg4 [plasma membrane]

Stable Identifier

R-RNO-9612601

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

Psd-95

Locations in the PathwayBrowser

Expand all

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL:ACTN2 [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4:NEFL [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:DLG4:DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        DLG1,DLG2,DLG3,DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
  - Signaling by Rho GTPases (Rattus norvegicus)
    - RHO GTPase Effectors (Rattus norvegicus)
      - RHO GTPases activate CIT (Rattus norvegicus)
        
        CIT-3 binds DLG4 (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)
        
        RHOA,RHOB,RHOC,RAC1:GTP:CIT-3:DLG4 [plasma membrane] (Rattus norvegicus)
        
        Dlg4 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P31016 Dlg4

Gene Names

Dlg4, Dlgh4, Psd95

Chain

chain:1-724

Reference Genes

BioGPS Gene:29495 Dlg4

KEGG:rno:29495 Dlg4

Monarch:29495 Dlg4

NCBI Gene:29495 Dlg4

UCSC:P31016 Dlg4

Reference Transcript

RefSeq:NM_019621.1 Dlg4

Participates

as a component of

as an input of

as a member of

Other forms of this molecule

Dlg4 [endocytic vesicle membrane]

Dlg4 [cytosol]

Inferred From

DLG4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_062567.1

PRO

P31016

RGD

68424

PDB

1RGR, 5HDY, 7CQF, 5YPO, 5YPR, 1QLC, 1IU2, 1IU0, 5D13, 1JXO, 5HEB, 1BFE, 3GSL, 5HED, 1TP3, 5W72, 5MZ7, 7F7G, 5HF1, 2MHO, 5HF4, 7F7I, 2XKX, 2KA9, 5HET, 5B64, 3WP0, 5HFC, 5HFD, 3WP1, 1TQ3, 1KJW, 1TP5, 1BE9, 5HFB, 5HEY, 5HFE, 1JXM, 5HFF, 5GNV

Interactors (43)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q00960 Grin2b	7	GRIN2B [plasma membrane] (R-RNO-419558) Grin2b [plasma membrane] (R-RNO-6794241) GRIN2B [endoplasmic reticulum membrane] (R-RNO-9609765) Grin2b [endoplasmic reticulum membrane] (R-RNO-9609846) p-Y-Grin2b [plasma membrane] (R-RNO-9628248) p-Y1472-Grin2b [plasma membrane] (R-RNO-9032617) phospho-p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-RNO-3928477)	0.915	11
UniProt:P97836 Dlgap1	2	Gkap1 [plasma membrane] (R-RNO-6794237) Dlgap1 [plasma membrane] (R-RNO-6794239)	0.843	9
UniProt:Q00959 Grin2a	3	Grin2a [plasma membrane] (R-RNO-6794271) Grin2a [endoplasmic reticulum membrane] (R-RNO-9609845) p-Y-Grin2a [plasma membrane] (R-RNO-9628245)	0.791	8
UniProt:P34926 MAP1A			0.784	16
UniProt:P35439 Grin1	2	Grin1 [plasma membrane] (R-RNO-9610826) Grin1 [endoplasmic reticulum membrane] (R-RNO-9609841)	0.708	4
UniProt:P22459 KCNA4	1	KCNA4 [plasma membrane] (R-HSA-977474)	0.676	3
UniProt:P19490 Gria1	7	GRIA1 [plasma membrane] (R-RNO-3004495) GRIA1 [endocytic vesicle membrane] (R-RNO-3004479) Gria1 [plasma membrane] (R-RNO-9620440) p-S849-Gria1 [plasma membrane] (R-RNO-9620442) GRIA1 [endoplasmic reticulum membrane] (R-RNO-5689460) GRIA1 [ER to Golgi transport vesicle membrane] (R-RNO-5689810) GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-RNO-5689811)	0.649	5
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.645	9
UniProt:P08588 ADRB1	1	ADRB1 [plasma membrane] (R-HSA-390653)	0.623	2
UniProt:O54857 PTEN			0.612	5
UniProt:P28572-2 SLC6A9			0.602	4
UniProt:Q9WVI4 Gucy1a2	2	Guanylate cyclase soluble subunit alpha-2 [cytosol] (R-RNO-427260) Gucy1a2 [cytosol] (R-RNO-391996)	0.602	7
UniProt:Q9Z252 Lin7b	1	Lin7b [plasma membrane] (R-RNO-6794272)	0.599	6
UniProt:Q91ZD4 Vangl2	2	pS5,S82,S84-Vangl2 [plasma membrane] (R-MMU-4551502) Vangl2 [plasma membrane] (R-MMU-4551496)	0.591	6
UniProt:Q12959-2 DLG1			0.591	9
UniProt:O08560	1	Dgkz [plasma membrane] (R-RNO-426060)	0.59	6
UniProt:Q71RJ2	2	Cacng2 [plasma membrane] (R-RNO-210375) Cacng2 [endocytic vesicle membrane] (R-RNO-416846)	0.589	2
UniProt:Q9WV48 Shank1	2	Shank1 [cytosol] (R-RNO-6794229) Shank1 [cytosol] (R-RNO-6794274)	0.564	3
UniProt:Q62696 Dlg1	4	Dlg1 [plasma membrane] (R-RNO-9617427) Dlg1 [endoplasmic reticulum membrane] (R-RNO-9610616) Dlg1 [cytosol] (R-RNO-416332) Dlg1 [plasma membrane] (R-RNO-375977)	0.564	3
UniProt:Q13224 GRIN2B	6	GRIN2B [plasma membrane] (R-HSA-419558) GRIN2B [endoplasmic reticulum membrane] (R-HSA-9609765) GRIN2B [transport vesicle membrane] (R-HSA-9610568) p-Y-GRIN2B [plasma membrane] (R-HSA-9612185) p-Y1474-GRIN2B [plasma membrane] (R-HSA-9032602) p-Y1252,Y1336,Y1474-GRIN2B [plasma membrane] (R-HSA-3928477)	0.558	2
UniProt:Q12879 GRIN2A	3	GRIN2A [plasma membrane] (R-HSA-419556) GRIN2A [endoplasmic reticulum membrane] (R-HSA-9609760) p-Y-GRIN2A [plasma membrane] (R-HSA-9612190)	0.558	2
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189)	0.558	2
IntAct:EBI-16035555 CRIPT-1			0.558	2
UniProt:Q9P021 CRIPT			0.558	2
UniProt:P70587 Lrrc7	4	Lrrc7 [extracellular region] (R-RNO-6799681) Lrrc7 [specific granule lumen] (R-RNO-6799616) Lrrc7 [cytosol] (R-RNO-9611392) Lrrc7 [cytosol] (R-RNO-9611351)	0.556	5
UniProt:Q6IN36	1	Wipf1 [cytosol] (R-RNO-201874)	0.556	5
UniProt:Q9Z1T4	1	Cnksr2 [cytosol] (R-RNO-5672632)	0.556	4
UniProt:F1MAB7	1	Dgki [plasma membrane] (R-RNO-426064)	0.556	4
UniProt:P30937	1	Sstr4 [plasma membrane] (R-RNO-374745)	0.556	3
UniProt:Q00961 Grin2c	5	GRIN2C [plasma membrane] (R-RNO-419560) Grin2c [plasma membrane] (R-RNO-9614232) GRIN2C [endoplasmic reticulum membrane] (R-RNO-9609761) Grin2c [endoplasmic reticulum membrane] (R-RNO-9610096) p-Y-Grin2c [plasma membrane] (R-RNO-9628252)	0.553	2
UniProt:P70478	6	Apc [nucleoplasm] (R-RNO-3361755) phospho-Apc [cytosol] (R-RNO-3009421) Apc [cytosol] (R-RNO-5246690) Apc [cytosol] (R-RNO-2976014) Apc [cytosol] (R-RNO-2976013) Apc [cytosol] (R-RNO-2976015)	0.544	2
UniProt:Q80Z96	1	Vangl1 [plasma membrane] (R-MMU-9714275)	0.544	4
UniProt:P97837	1	Dlgap2 [plasma membrane] (R-RNO-6794266)	0.527	2
UniProt:Q62765-1 NLGN1			0.527	2
UniProt:P20595 Gucy1b3	1	Guanylate cyclase soluble subunit beta-1 [cytosol] (R-RNO-427265)	0.524	2
UniProt:P28572	1	Slc6a9 [plasma membrane] (R-RNO-444127)	0.524	2
UniProt:Q8R4T5 GRASP			0.524	3
UniProt:P10608	5	phospho-Adrb2 [clathrin-coated endocytic vesicle membrane] (R-RNO-8869143) Adrb2 [endosome membrane] (R-RNO-6783036) Adrb2 [endosome membrane] (R-RNO-6783066) phospho-Adrb2 [plasma membrane] (R-RNO-8852158) Adrb2 [plasma membrane] (R-RNO-390647)	0.499	2
UniProt:Q5XIE8 ITM2B			0.499	5
UniProt:Q460M5	1	Lrfn2 [plasma membrane] (R-RNO-197665)	0.463	3
UniProt:Q8VHW5	2	Cacng8 [plasma membrane] (R-RNO-210486) Cacng8 [endocytic vesicle membrane] (R-RNO-416848)	0.463	2
UniProt:Q9EQL9 Sharpin	1	Sharpin [cytosol] (R-RNO-6794270)	0.463	2
UniProt:Q9JJ40 NHRF3			0.463	2

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