Unblocking of Grin1:Grin2 NMDA receptors

Stable Identifier
R-RNO-9614351
Type
Reaction [dissociation]
Species
Rattus norvegicus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Unblocking of Grin1:Grin2 NMDA receptors
Upon depolarization of rat neurons by the influx of Na+, Mg2+ is removed from the pore of GluN1:GluN2 (Grin1:Grin2) NMDA receptors, resulting in activation of ligand-bound receptors (Clarke et al. 2013).
Literature References
PubMed ID Title Journal Year
23447622 Mechanistic and structural determinants of NMDA receptor voltage-dependent gating and slow Mg2+ unblock

Johnson, JW, Glasgow, NG, Clarke, RJ

J. Neurosci. 2013
Participants
Input
Output
This event is regulated
Requirements
Orthologous Events
Unblocking of GRIN1:GRIN2 NMDA receptors (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-07-24)
Reviewed
Gillespie, ME  (2018-07-28)
D'Eustachio, P  (2018-07-27)
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-07-25)
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