Egr2, Sox10 and Smarca4 bind the Mpz gene

Stable Identifier
R-RNO-9614784
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Egr2, Sox10 and Smarca4 bind the Mpz gene

Myelin protein zero (Mpz) is a primary component of the myelin sheath that surrounds axons in the peripheral and central nervous system. Mpz expression in activated in the peripheral nervous system by the binding of Sox10 and Egr2, 2 key regulators of peripheral myelination, to binding sites in intron 1. Activation is facilitated by the recruitment of SMARCA4, a component of SWI/SNF chromatin remodelling complexes (Le Blanc et al, 2006; Le Blanc et al, 2007; Marathe et al, 2013). Sox10 also binds to elements in the Mpz promoter (Peirano et al, 2000).

Literature References
PubMed ID Title Journal Year
23874858 SWI/SNF enzymes promote SOX10- mediated activation of myelin gene expression

Yeung, KC, Datar, I, Zhang, X, Mehta, G, Marathe, HG, Mehrotra, A, de la Serna, IL

PLoS ONE 2013
10757804 Protein zero gene expression is regulated by the glial transcription factor Sox10

Goerich, DE, Wegner, M, Riethmacher, D, Peirano, RI

Mol. Cell. Biol. 2000
17325040 Neuropathy-associated Egr2 mutants disrupt cooperative activation of myelin protein zero by Egr2 and Sox10

Ward, RM, Svaren, J, Leblanc, SE

Mol. Cell. Biol. 2007
16373334 Direct regulation of myelin protein zero expression by the Egr2 transactivator

Wrabetz, L, Ward, RM, Svaren, J, Jang, SW, Leblanc, SE

J. Biol. Chem. 2006
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Orthologous Events
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