Egr2 and Sox10 bind Mbp1 gene

Stable Identifier
R-RNO-9615634
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
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Egr2 and Sox10 bind Mbp1 gene

As assesssed by ChIP from S16 cells, Egr2 binds to cognate sites in the enhancer and first intron of the Mbp gene (Jang et al, 2006). By conservation of sites, Sox10 is predicted to potentiate Egr2-dependent expression of Mbp, as it does for other myelination proteins, and ChIP-seq analsys and Sox10 knockdown in mouse supports this prediction (Jones et al, 2007; Lopez-Arido et al, 2015)

Literature References
PubMed ID Title Journal Year
18634568 Interactions of Sox10 and Egr2 in myelin gene regulation

Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J

Neuron Glia Biol. 2007
25974668 Differential Sox10 genomic occupancy in myelinating glia

Lopez-Anido, C, Sun, G, Koenning, M, Srinivasan, R, Hung, HA, Emery, B, Keles, S, Svaren, J

Glia 2015
16923174 In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

Jang, SW, Leblanc, SE, Roopra, A, Wrabetz, L, Svaren, J

J. Neurochem. 2006
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Orthologous Events
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