Hspa8 binds Rnase1

Stable Identifier
R-RNO-9615712
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Hspa8 binds Rnase1
Intracellular proteins are targeted for proteolytic degradation in the lysosome with the aid of chaperones. Heat shock cognate 71 kDa protein (Hspa8) acts as the constitutive chaperone that binds Ribonuclease pancreatic beta-type (Rnase1) in the cytosol. Hspa8 recognizes a motif on Rnase1 based on the charge of amino acids (Chiang H et al. 1989). Once bound with Hspa8, the substrates are targeted to the lysosome or endosome.
Literature References
PubMed ID Title Journal Year
2799391 A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

Dice, JF, Plant, CP, Terlecky, SR, Chiang, HL

Science 1989
Participants
Orthologous Events
Authored
Reviewed
Created
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