Egr2 and Sox10 bind the Prx promoter

Stable Identifier
R-RNO-9619658
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
General
SVG |   | PPTX  | SBGN
Egr2 and Sox10 bind the Prx promoter

ChIP seq analysis shows that EGR2 and SOX10 bind to an intronic element in the Prx gene in rat S16 cells, consistent with the known dependence of Prx expression on Egr2 and Sox10 (Jones et al, 2007; Srinivasan et al, 2012; Nagarajan et al, 2001; Bondurand et al, 2001)

Literature References
PubMed ID Title Journal Year
22492709 Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

Srinivasan, R, Sun, G, Keles, S, Jones, EA, Jang, SW, Krueger, C, Moran, JJ, Svaren, J

Nucleic Acids Res. 2012
11734543 Human Connexin 32, a gap junction protein altered in the X-linked form of Charcot-Marie-Tooth disease, is directly regulated by the transcription factor SOX10

Bondurand, N, Girard, M, Pingault, V, Lemort, N, Dubourg, O, Goossens, M

Hum. Mol. Genet. 2001
18634568 Interactions of Sox10 and Egr2 in myelin gene regulation

Jones, EA, Jang, SW, Mager, GM, Chang, LW, Srinivasan, R, Gokey, NG, Ward, RM, Nagarajan, R, Svaren, J

Neuron Glia Biol. 2007
11394999 EGR2 mutations in inherited neuropathies dominant-negatively inhibit myelin gene expression

Nagarajan, R, Svaren, J, Le, N, Araki, T, Watson, M, Milbrandt, J

Neuron 2001
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Orthologous Events
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