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Hspa8:Substrate dissociates from Lamp2 multimer
Stable Identifier
R-RNO-9626028
Type
Reaction [dissociation]
Species
Rattus norvegicus
Compartment
lysosomal lumen
,
lysosomal membrane
ReviewStatus
5/5
General
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BioPAX
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Heat shock cognate 71 kDa protein (Hspa8) translocates substrates from the cytosol to the lysosomal membrane where it binds to Lysosome-associated membrane glycoprotein 2 (Lamp2a). The Lamp2a complex then multimerizes and stabilizes. Subsequently, the substrate unfolds and translocates to the lumen. The substrate bound Hspa8 then dissociates from Lamp2a multimer (Agarraberes FA et al. 1997, Cuervo AM et al. 1997). The function of Lamp2a multimer is now complete and starts to disassemble.
Literature References
PubMed ID
Title
Journal
Year
9151685
An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation
Dice, JF
,
Agarraberes, FA
,
Terlecky, SR
J. Cell Biol.
1997
9038169
A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins
Dice, JF
,
Cuervo, AM
,
Knecht, E
J. Biol. Chem.
1997
Participants
Input
Hspa8:Lamp2 multimeric complex [lysosomal membrane]
(Rattus norvegicus)
Output
Hsp8:Substrate [lysosomal lumen]
(Rattus norvegicus)
Lamp2 multimer complex: Gfap [lysosomal membrane]
(Rattus norvegicus)
Orthologous Events
HSPA8:Substrate dissociates from LAMP2a multimer (Homo sapiens)
Authored
Varusai, TM (2019-11-08)
Reviewed
Metzakopian, E (2019-02-22)
Created
Varusai, TM (2018-10-25)
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